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RTN3 Antibody

  • 中文名称：
    RTN3兔多克隆抗体
  • 货号：
    CSB-PA020570GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O95197
  • 基因名：
    RTN3
  • 别名：
    ASYIP antibody; Neuroendocrine specific protein like 2 antibody; Neuroendocrine-specific protein-like 2 antibody; Neuroendocrine-specific protein-like II antibody; NSP like protein II antibody; NSP-like protein 2 antibody; NSP-like protein II antibody; NSPL2 antibody; NSPLII antibody; Reticulon 3 antibody; Reticulon-3 antibody; Reticulon3 antibody; Rtn3 antibody; RTN3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human RTN3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules.
  • 基因功能参考文献：
    1. RTN3 regulates very low density lipoprotein (VLDL) secretion by controlling VLDL transport vesicle-mediated endoplasmic reticulum-to-Golgi transport of nascent VLDL. PMID: 29756473
    2. Here, the s identified reticulon 3 (RTN3) as a specific receptor for the degradation of endoplasmic reticulum tubules. None of the other reticulon family members have the ability to induce fragmentation of endoplasmic reticulum tubules during starvation. PMID: 28617241
    3. RTN3 was critical for EGFR-nonclathrin endocytosis (NCE), promoting the creation of plasma membrane - endoplasmic reticulum contact sites that were required for the formation and/or maturation of NCE invaginations. PMID: 28495747
    4. This study demonstrated that higher intrahepatic RTN3 levels were independently associated with higher intrahepatic HCV viral loads and genotype 1 in HCV-related hepatocellular carcinoma PMID: 28551625
    5. These results suggested that RTN3 modulates primordial germ cell migration through interaction with, and regulation of, CXCR4. PMID: 27070582
    6. RTN 3 interacts with the N-terminal domain of EV71 2C, which is crucial for replication of viral RNA. [Review] PMID: 26164948
    7. s demonstrated that the second transmembrane region of RTN3 competed for, and bound to, the AH2 domain of hepatitis C virus NS4B, thus abolishing NS4B self-interaction and leading to the downregulation of viral replication. PMID: 24898729
    8. In Alzheimer's disease transgenic mouse models, RTN3 deficiency facilitates amyloid deposition. PMID: 25319692
    9. This study demonistrated that Reduction of beta-amyloid accumulation by reticulon 3. PMID: 22742855
    10. successful prevention of imunoreactive dystrophic neurites formation should be initiated before RTN3 aggregation PMID: 23407961
    11. we hypothesis that RTN3 may participate in the continuous process of circulating monocyte recruitment in atherosclerosis. PMID: 21964562
    12. we examined reticulon-3 expression in cases of Alzheimer's disease, Parkinson's disease, and diffuse Lewy body disease PMID: 20374499
    13. Reticulons, the only molecular so far to participate in all three apoptosis signaling pathways, may be a novel player in the progress of atherosclerosis. PMID: 20717916
    14. common genetic variation in the BACE1-interacting proteins, RTN3 an PPIL2, does not influence platelet b-secretase activity or susceptibility to Alzheimer's disease in this population. PMID: 19669607
    15. CRELD1 could partly change the localization of RTN3 from the endoplasmic reticulum to the plasma membrane and modulate the apoptotic activity of RTN3 through binding with it. PMID: 19521671
    16. RTN3 mutants w/o the N-terminal or C-terminal or loop domain bound BACE1 like wild-type & reduced Abeta40/42 secretion. Mutants of the the 1st or 2d potential transmembrane domains bound BACE1 but failed to inhibit Abeta secretion. PMID: 19405102
    17. The ASYIP protein co-localizes with ASY in the endoplasmic reticulum. Characterization of the ASYIP gene helps to clarify ASY-induced apoptosis or Nogo-involved inhibition of neuronal regeneration in the central nervous system. PMID: 12811824
    18. RTN3 isoforms may contribute, by as yet unknown mechanisms, to neuronal survival and plasticity PMID: 15350194
    19. apoptosis-inducing protein, HAP, induces bacterial cell death [HAP, homolog of ASY protein] PMID: 15560370
    20. These results suggest that RTN3 plays a role in membrane trafficking in the early secretory pathway. PMID: 16054885
    21. All the results indicate that both the mitochondria and the endoplasmic reticulum (ER) are involved in apoptosis caused by HAP overexpression, and suggest that HAP overexpression may initiate an ER overload response (EOR). PMID: 16847569
    22. Results describe the mapping of interaction domains mediating binding between BACE1 and RTN3/Nogo proteins. PMID: 16979658
    23. Endoplasmic reticulum, ER-bound RTN3 protein recruited endogenous FADD to the ER membrane and subsequently initiated caspase-8 cascade, including activation of caspase-8, processing of Bid and release of cytochrome c from mitochondria. PMID: 17031492
    24. These findings indicate that RTN3 is directly involved in the endoplasmic reticulum-constituents trafficking events through dually acting as an essential and important ER-stress sensor, and a trigger for the Bcl-2 translocation. PMID: 17191123
    25. In normal HeLa cells, ectopic overexpressed Bcl-2 reduced the cell apoptosis induced by overexpressed RTN3. results suggest that RTN3 could bind with Bcl-2 and mediate its accumulation in mitochondria, which modulate the anti-apoptotic activity of Bcl-2. PMID: 17379544
    26. the membrane topology of RTN3 has an effect on binding of RTN3 to BACE1 PMID: 17699523
    27. These results show that RTN3 is primarily expressed in pyramidal neurones of the human cerebral cortex and that no clear difference of RTN3 immunoreactivity is observable between control and Alzheimer's disease brains. PMID: 19284479
    28. the disordered C-terminus of RTN3 is able to interact with FADD via a novel mode previously unobserved for FADD. PMID: 19364499
    29. Elevated levels of RTN3 in transgenic RTN3 mice lead to an imbalance in the axonal transport of RTN3, which results in the accumulation of RTN3 in swollen neurites. PMID: 19386906

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
  • 组织特异性：
    Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain an
  • 数据库链接：

    HGNC: 10469

    OMIM: 604249

    KEGG: hsa:10313

    STRING: 9606.ENSP00000344106

    UniGene: Hs.743229