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SCYL2 Antibody

  • 中文名称：
    SCYL2兔多克隆抗体
  • 货号：
    CSB-PA020874GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q6P3W7
  • 基因名：
    SCYL2
  • 别名：
    AU015688 antibody; AW536445 antibody; BC030932 antibody; Coated vesicle-associated kinase of 104 kDa antibody; CVAK104 antibody; D10Ertd802e antibody; FLJ10074 antibody; KIAA1360 antibody; RGD1305665 antibody; SCY1 like 2 (S. cerevisiae) antibody; SCY1 like protein 2 antibody; SCY1-like protein 2 antibody; SCYL2 antibody; SCYL2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human SCYL2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system. A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed. By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development.
  • 基因功能参考文献：
    1. results suggest that SCYL2 serves as a regulatory factor for Vpu, reducing the extent of Vpu phosphorylation and consequently enhancing BST2-mediated viral restriction. PMID: 23047923
    2. CVAK104 binds ATP and functions in vitro as a poly-L-lysine-stimulated kinase that is capable of autophosphorylation and phosphorylating the beta2-adaptin subunit of AP2. PMID: 15809293
    3. Together, our data suggest a function for CVAK104 in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. PMID: 16914521
    4. CVAK104 is an evolutionarily conserved protein involved in SNARE sorting that is essential for normal embryonic development PMID: 17587408
    5. Studies identify CVAK104 as a novel binding partner of Dishevelled (Dvl) and that CVAK104 also interacts with Fzd5. PMID: 19643732

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  • 亚细胞定位：
    Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network membrane. Endosome membrane.
  • 蛋白家族：
    Protein kinase superfamily
  • 数据库链接：

    HGNC: 19286

    OMIM: 616365

    KEGG: hsa:55681

    STRING: 9606.ENSP00000354061

    UniGene: Hs.506481