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SIGLEC1 Antibody

  • 中文名称：
    SIGLEC1兔多克隆抗体
  • 货号：
    CSB-PA005635
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of K562 cells using CD169 Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q9BZZ2
  • 基因名：
    SIGLEC1
  • 别名：
    CD169 antibody; CD169 antigen antibody; dJ1009E24.1 antibody; DKFZp667F058 antibody; FLJ00051 antibody; FLJ00055 antibody; FLJ00073 antibody; FLJ00411 antibody; FLJ32150 antibody; Sialic acid binding Ig like lectin 1 antibody; sialic acid binding Ig-like lectin 1; sialoadhesin antibody; Sialic acid binding immunoglobulin like lectin 1 antibody; Sialic acid-binding Ig-like lectin 1 antibody; Sialoadhesin antibody; Siglec 1 antibody; Siglec-1 antibody; Siglec1 antibody; SN antibody; SN_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CD169.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis.
  • 基因功能参考文献：
    1. SIGLEC1 mRNA levels have potential as a novel predictive biomarker for Graves disease relapse. PMID: 29037117
    2. classical HIV-1 infectious routes may compensate for the lack of Siglec-1 in fuelling HIV-1 dissemination within infected individuals PMID: 27510803
    3. Our findings evidenced for the first time the novel association between SIGLEC1 rs3859664 SNP and active pulmonary TB. Intriguingly, carriers of the polymorphism produced less IL-1ss than non-carriers, suggesting the possible involvement of Siglec-1 signalling pathway with inflammasome complex. PMID: 28964857
    4. the antibody-sialidase conjugate desialylated tumor cells in a HER2-dependent manner, reduced binding by natural killer (NK) cell inhibitory sialic acid-binding Ig-like lectin (Siglec) receptors, and enhanced binding to the NK-activating receptor natural killer group 2D (NKG2D). PMID: 27551071
    5. The results reveal marked differences between afferent and efferent ymphatic endothelial cells and identify molecules on lymphatic vessels. Further characterizations of Siglec-1 (CD169) and macrophage scavenger receptor 1 (MSR1/CD204), show that they are discriminatively expressed on lymphatic endothelium of the subcapsular sinus but not on lymphatic vasculature of the lymphatic sinus PMID: 27601677
    6. High CD169 expression is associated with HIV-1. PMID: 28794041
    7. CD169 expression in regional LNs was not associated with PSA-relapse. PMID: 28880401
    8. These results highlight the importance of sialic acids on the V1V2 region in binding to sialic acid-binding immunoglobulin-like lectin. PMID: 26667473
    9. High expression of SIGLEC1 in pregnant women with autoantibodies against Ro/SS-A indicates an enhanced risk for autoimmune congenital heart block development. PMID: 28501799
    10. These data demonstrate a prominent role for Siglec-1 in the internalization of HIV-1 to the virus-containing compartment in infected monocyte-derived macrophages PMID: 28129379
    11. this study shows that binding of monoclonal antibodies to Sn results in delayed and reduced phagocytosis of fluorescent beads, and that no effect is observed on Fc-mediated phagocytosis or phagocytosis of bacteria by macrophages PMID: 27993350
    12. These findings suggest that CD169+ macrophages in RLNs might be a useful marker for assessing clinical stage, including LN states, in patients with breast cancer. PMID: 27861544
    13. CD169 might act as a co-stimulatory molecule for cytotoxic T-cell activation, and could define a population of tumour-infiltrating macrophages with potential anti-tumour properties in human hepatocellular carcinoma tissues. PMID: 27174787
    14. In colorectal tumor, malignant melanoma, and endometrial tumor, it was shown that a high density of CD169-positive macrophages in the lymph node sinus was a predictive factor for better clinical prognosis. PMID: 28002629
    15. Siglec-1 and Siglec-2 are potential biomarkers in autoimmune disease. (Review) PMID: 26752092
    16. Siglec-1 on myeloid cells could fuel novel CD4(+) T-cell infections and contribute to HIV-1 dissemination in vivo. PMID: 25947229
    17. evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans-infection of T cells PMID: 25033082
    18. Our study suggests that HIV-1 capture by CD169 can provide virus evasion from both innate (phagocytosis) and adaptive immune responses PMID: 25760631
    19. GM3-CD169 binding is a gp120-independent signal for sequestration and preservation of HIV-1 infectivity. PMID: 24947940
    20. The most abundant cytokine present in semen (TGF-beta1) is able to enhance specifically the expression of an important molecule (CD169) involved in the capture and transmission of HIV-1 particles from the mucosal lumen to the submucosal compartment. PMID: 25354152
    21. Siglec-1 may play a proinflammatory role in stimulating lymphocyte proliferation and activation in rheumatoid arthritis. PMID: 24196391
    22. CD169(+) macrophages in RLNs promote CD8(+) T-cell-mediated antitumor immunity. PMID: 23734742
    23. downregulation of CD169 expression or neutralizing CD169 function abrogated dendritic cell-mediated HIV-1 capture and trans infection, while exogenous expression of CD169 in receptor-naive cells rescued glycosphingolipid-dependent capture and trans infection. PMID: 23593001
    24. Based on increased SIGLEC1 expression in circulating monocytes, findings suggest a role for SIGLEC1 in the chronic progressive phases of multiple sclerosis. PMID: 22933622
    25. the CD169/Sn endocytic pathway is conserved and capable of presenting lipid antigens to iNKT cells PMID: 23610394
    26. These findings identify Siglec-1 as a key factor for HIV-1 spread via infectious dendritic/T-cell synapses. PMID: 23271952
    27. Monocytes overexpress sialoadhesin nonspecifically during intestinal transplant rejection and systemic or enteritic inflammatory states. PMID: 22249367
    28. Increased expression in monocytes of patients with primary biliary cirrhosis PMID: 20653431
    29. Sialoadhesin is induced to high levels on CD14(+) cells early after HIV-1 infection in vivo. PMID: 17330143
    30. Data show that the combinatorial signal delivered by R-DC to T cells via B7-H1 and sialoadhesin is crucial for the induction of IL-35(+) Treg. PMID: 19950173
    31. Inhibitory signals delivered from human rhinovirus HRV14-treated dendritic cells to cocultured T cells via sialoadhesin (Sn) are critical for induction of T-cell anergy. PMID: 16002716
    32. Increased expression of Siglec-1 in circulating systemic sclerosis (SSc) monocytes and tissue macrophages suggests type I IFN-mediated activation of monocytes occurs in SSc, possibly through toll-like receptor (TLR) activation of interferon secretion. PMID: 17328080
    33. Siglec-1 (sialic acid binding Ig-like lectin 1) expression in resident blood monocytes is a potential biomarker for monitoring disease activity, displaying type I IFN responses, and estimating levels of anti-dsDNA antibodies PMID: 18383365
    34. Increased sialoadhesin expression on CD14(+) monocytes occurs in response to HIV-1 infection with maximum expression associated with high viral load PMID: 18414664
    35. Siglec-1 may be considered as a potential non-invasive indicator for monitoring disease severity and a biomarker for predicting the relative risk of cardiovascular events. PMID: 19285973
    36. SIGLEC1, used as a surrogate marker for type I interferon, is a potential biomarker to assess disease acitvity in systemic lupus erythematosus (SLE). SIGLEC1+ resident monocytes could act as antigen presenting cells in SLE. PMID: 18383365

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  • 亚细胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 蛋白家族：
    Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
  • 组织特异性：
    Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophag
  • 数据库链接：

    HGNC: 11127

    OMIM: 600751

    KEGG: hsa:6614

    STRING: 9606.ENSP00000341141

    UniGene: Hs.31869