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  4. SYNPO2 Antibody

SYNPO2 Antibody

  • 中文名称：
    SYNPO2兔多克隆抗体
  • 货号：
    CSB-PA461485
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA461485(SYNPO2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA461485(SYNPO2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q9UMS6
  • 基因名：
    SYNPO2
  • 别名：
    DKFZp686G051 antibody; Genethonin 2 antibody; Genethonin-2 antibody; Myopodin antibody; striated muscle specific antibody; Synaptopodin-2 antibody; SYNP2_HUMAN antibody; SYNPO 2 antibody; Synpo2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human SYNPO2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks in an isoform-specific manner. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes. Involved in regulation of cell migration. May be a tumor suppressor.; Involved in regulation of cell migration. Can induce formation of thick, irregular actin bundles in the cell body.; Involved in regulation of cell migration. Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers.; Involved in regulation of cell migration. Can induce an amorphous actin meshwork throughout the cell body containing a mixture of long and short, randomly organized thick and thin actin bundles.; Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fibers.; Involved in regulation of cell migration in part dependent on the Rho-ROCK cascade; can promote formation of nascent focal adhesions, actin bundles at the leading cell edge and lamellipodia. Can induce formation of thick, irregular actin bundles in the cell body; the induced actin network is associated with enhanced cell migration in vitro.
  • 基因功能参考文献：
    1. These findings uncover a suppressive role of SYNPO2 in triple-negative breast cancer (TNBC) metastasis via inhibition of YAP/TAZ, and suggest that SYNPO2 might provide a potential prognosis marker and novel therapeutic strategy. PMID: 28991374
    2. LMOD1, SYNPO2, PDLIM7, PLN, and SYNM down-regulation reflect the altered phenotype of smooth muscle cells in vascular disease and could be early sensitive markers of SMC dedifferentiation. PMID: 27470516
    3. Results show that SYNPO2 gene plays an important role in the etiology of epithelial ovarian cancer, suggesting that this gene may be a potential genetic modifier for developing epithelial ovarian cancer. PMID: 28231729
    4. High Myopodin methylation is associated with metastasis in kidney cancer. PMID: 27592258
    5. High Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration. PMID: 25883213
    6. Promoter hypermethylation and down regulation of SYNPO2 has significance in the prognosis of melanoma patients. PMID: 25918983
    7. myopodin is epigenetically modified in colon cancer PMID: 22252522
    8. the N-terminus of myopodin binds integrin-linked kinase (ILK) both in vivo and in vitro PMID: 21643011
    9. myopodin functions as a tumor suppressor gene to limit the growth and to inhibit the metastasis of cancer cells PMID: 15111326
    10. Imp13 functions in myopodin import and the regulation of this event is critical for normal and abnormal cellular differentiation. PMID: 17828378
    11. The myopodin new isoform (Myo2), in addition to the two predicted isoforms (Myo1 and Myo3), are transcribed in various mammalian tumor cell lines. PMID: 18371299
    12. The subcellular localization of myopodin is involved in its suppressor or activator function in tumorigenesis. PMID: 19360353

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell junction, focal adhesion.; [Isoform 1]: Cytoplasm, cytoskeleton.; [Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 3]: Cytoplasm, cytoskeleton.; [Isoform 4]: Cytoplasm, cytoskeleton.; [Isoform 5]: Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Synaptopodin family
  • 组织特异性：
    Expressed in heart muscle. Isoform 5 is specifically expressed in skeletal muscle.
  • 数据库链接：

    HGNC: 17732

    KEGG: hsa:171024

    STRING: 9606.ENSP00000306015

    UniGene: Hs.655519