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TAF1 Antibody

  • 中文名称：
    TAF1兔多克隆抗体
  • 货号：
    CSB-PA023076GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P21675
  • 基因名：
    TAF1
  • 别名：
    BA2R antibody; CCG1 antibody; CCGS antibody; Cell cycle G1 phase defect antibody; Cell cycle gene 1 protein antibody; Complementation of cell cycle block G1 to S antibody; DYT3 antibody; N TAF1 antibody; NSCL2 antibody; OF antibody; p250 antibody; TAF 1 antibody; TAF(II)250 antibody; TAF1 antibody; TAF1 RNA polymerase II TATA box binding protein (TBP) associated factor 250kDa antibody; TAF1_HUMAN antibody; TAF2A antibody; TAFII-250 antibody; TAFII250 antibody; TATA box binding protein (TBP) associated factor RNA polymerase II A 250kD antibody; TBP associated factor 250 kDa antibody; TBP-associated factor 250 kDa antibody; Transcription factor TFIID p250 polypeptide antibody; Transcription initiation factor TFIID 250 kDa subunit antibody; Transcription initiation factor TFIID subunit 1 antibody; XDP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human TAF1-Specific
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4.
  • 基因功能参考文献：
    1. Our findings highlight the regulatory networks among TFs, lncRNAs, miRNAs, and mRNAs in hepatocellular carcinoma (HCC). Several key molecules, such as hsa-miR-195, lncRNA MALAT1 and TFs TAF1 and HNF4alpha, may contribute to the progression of HCC. PMID: 30249878
    2. These data directly link sequence variation within the XDP-specific SVA sequence to phenotypic variability in clinical disease manifestation and provide insight into potential mechanisms by which this intronic retroelement may induce transcriptional interference in TAF1 expression. PMID: 29229810
    3. present a case study where a combination of experimental techniques and computational simulations was used to comprehensively characterize the binding and structure-affinity relationships for a series of Bromosporine-based bivalent bromodomain ligands with a bivalent protein, Transcription Initiation Factor TFIID subunit 1 (TAF1). PMID: 29558110
    4. The results converge on TAF1 dysfunction in peripheral models of X-linked dystonia-parkinsonism, and provide evidence of altered expression of a canonical gene in this disease. Furthermore, this study illustrates a link between the previously described genetic alterations and TAF1 dysfunction at the transcriptome level. PMID: 26879577
    5. TAF1 and TAF1L genes harbored not only somatic mutations but also mutational ITH. PMID: 27571988
    6. N-TAF1 expression is impaired in X-linked dystonia-parkinsonism. PMID: 26769797
    7. The bromodomains of BRD9, CECR2, and the second bromodomain of TAF1 recognize the longer butyryl mark on histones. In addition, the TAF1 second bromodomain is capable of binding crotonyl marks. PMID: 26365797
    8. TAF1 variants are associated with dysmorphic features, intellectual disability, and neurological manifestations. PMID: 26637982
    9. are necessary and sufficient to overcome the barrier of species specificity for human rDNA transcription in mouse cells PMID: 24928901
    10. TAF1 winged helix domain has intrinsic DNA-binding activity, which depends on characteristic residues that are commonly used by winged helix fold proteins for interacting with DNA. PMID: 25412659
    11. the surface of the TAF1-TAF7 complex contains two prominent conserved surface pockets, one of which binds selectively to an inhibitory trimethylated histone H3 PMID: 24927529
    12. This study demonistrated that frequencies of polymorphic genotype and allele of TAF1 gene were not different in patients than in control group and that they were not significant for cerebral venous thrombosis. PMID: 23264082
    13. As cellular ATP levels recover, TAF1 is able to phosphorylate p53 on Thr55, which leads to dissociation of p53 from the p21 promoter. PMID: 24289924
    14. Lower efficiency of microRNA synthesis directed by TATA box or NF-kappaappaB is a consequence of frequent transcription initiations that lead to RNA polymerase II crowding at pause sites and premature termination. PMID: 23831825
    15. Although d3-d4 also affect genes potentially related to neurodegenerative processes, their physiologic role as splice variants of TAF1 awaits further exploration PMID: 23184149
    16. analysis of phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7 PMID: 22711989
    17. In the Brazilian population, genetic variations in both uPA and TAFI were not relevant to endometriosis and/or infertility. PMID: 21819230
    18. TAF7, until now considered only a TFIID component and regulator of TAF1-dependent transcription, also regulates TAF1-independent transcription PMID: 20937824
    19. 285 patients with autosomal -dominant ataxia were examined, and abnormal or borderline expansions of CAG/CAA within TBP were found. PMID: 20587494
    20. Results indicate that increased TAF1 expression is associated with progression of human prostate cancers to the lethal castration-resistant state. PMID: 20181722
    21. polymorphism of TAF1 gene does not influence the risk of myocardial infarction. PMID: 11871391
    22. Evidence that TAF-TATA box-binding protein interactions are required for activated transcription in mammalian cells. PMID: 11909971
    23. TAF1 may be involved in the coordinate expression of Pol I- and Pol II-transcribed genes required for protein biosynthesis and cell cycle progression. PMID: 12498690
    24. TAFI polymorphisms investigated exerted no thrombogenic influence in pediatric oncology patients. PMID: 14719174
    25. TAF1 induces G1 progression in a p53-dependent manner. It interacts with and phosphorylates p53 at Thr-55 in vivo. PMID: 15053879
    26. hsTAF1 derepression of transcription requires the leucine zipper domain of c-Jun to bind to the N terminus of hsTAF1 PMID: 15087451
    27. TAF1-dependent histone acetylation facilitates transcription factor binding to the Sp1 sites, thereby activating cyclin D1 transcription and ultimately G(1)-to-S-phase progression PMID: 15870300
    28. DYT3 is the gene responsible for X-linked recessive dystonia-parkinsonism. PMID: 16366515
    29. linkage disequilibrium observed in an African population enabled us to identify the 1583T>A SNP located in 3'UTR. PMID: 16705091
    30. Downregulates E3 ubiquitin ligase Mdm2 auto-ubiquitylation, leading to Mdm2 stabilization, and promotes p53-Mdm2 association. PMID: 17237821
    31. Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism PMID: 17273961
    32. possible sites in hUBF HMG box 5 that may interact with the first bromodomain of TAF1 were proposed PMID: 17505112
    33. Thirty-eight exons code for TAF1. Five downstream exons of yet unknown function can either form transcripts with TAF1 exons or be transcribed independently. Splice variants can include d plus at least 12 TAF1 exons. PMID: 17952504
    34. CK2 is tightly associated with TAFII250 and is the principal activity responsible for TAFII250-mediated phosphorylation of Mdm2. PMID: 18548200
    35. interacts with human papillomavirus 16 E2 protein. PMID: 18580066

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  • 相关疾病：
    Dystonia 3, torsion, X-linked (DYT3); Mental retardation, X-linked, syndromic, 33 (MRXS33)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TAF1 family
  • 数据库链接：

    HGNC: 11535

    OMIM: 300966

    KEGG: hsa:6872

    STRING: 9606.ENSP00000276072

    UniGene: Hs.158560