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TSC22D1 Antibody

  • 中文名称：
    TSC22D1兔多克隆抗体
  • 货号：
    CSB-PA070159
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q15714
  • 基因名：
    TSC22D1
  • 别名：
    Cerebral protein 2 antibody; DKFZp686O19206 antibody; Hucep 2 antibody; Hucep2 antibody; KIAA1994 antibody; MGC17597 antibody; OTTHUMP00000040978 antibody; Ptg 2 antibody; Regulatory protein TSC 22 antibody; Regulatory protein TSC-22 antibody; Regulatory protein TSC22 antibody; RP11 269C23.2 antibody; T22D1_HUMAN antibody; TGFB stimulated clone 22 homolog antibody; TGFB-stimulated clone 22 homolog antibody; TGFB1I4 antibody; TGFbeta stimulated clone 22 antibody; Transcriptional regulator TSC 22 antibody; Transforming growth factor beta 1 induced transcript 4 antibody; Transforming growth factor beta 1 induced transcript 4 protein antibody; Transforming growth factor beta stimulated protein TSC 22 antibody; Transforming growth factor beta-1-induced transcript 4 protein antibody; TSC 22 antibody; TSC22 antibody; TSC22 domain family 1 isoform 2 antibody; TSC22 domain family member 1 antibody; TSC22 domain family protein 1 antibody; TSC22D1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human TSC-22.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter.
  • 基因功能参考文献：
    1. TSC22 could suppress tumor by inhibiting cell proliferation in colorectal cancer cell lines. Multivariate Cox regression analysis confirmed TSC22 expression as independent predictors of the OS in CRC patients PMID: 29481799
    2. TSC-22 acts as a tumor suppressor by safeguarding p53 from poly-ubiquitination mediated-degradation. PMID: 22870275
    3. we report that induced Tsc-22 leads to enhancement of TGF-beta-dependent signaling and enhancement is blocked by expression of a dominant-negative Tsc-22 mutant PMID: 21881999
    4. Differential regulation of antagonistic TSC22D1 variants is required for the establishment of oncogene-induced cellular senescence. PMID: 21448135
    5. Results support role of TSC22D1 as an enhancer of CNP transcription and suggest that TGF-beta-induced upregulation of CNP expression in smooth muscle may be mediated in part by increased transcription of TSC22D1. PMID: 20802130
    6. Long form of TSC22DF is evolutionarily conserved and has growth-regulating potential. PMID: 20149264
    7. Leucine Zipper structure of TSC22 markedly inhibits the anchorage independent growth of salivary gland cancer cells PMID: 11836610
    8. TSC-22 is an important downstream component of PPARgamma and TGF-beta signaling during intestinal epithelial cell differentiation PMID: 12468551
    9. findings suggest that the TSC-22 gene (-396) A allele is associated with an increasing risk of diabetic nephropathy PMID: 12757981
    10. Upregulation of TSC-22 mRNA by TGF-beta 1 is achieved by mRNA stabilization. PMID: 12767908
    11. Tsc-22 modulates the TGF-beta-dependant signaling pathway and binds to and modulate the transcriptional activity of Smad3 and Smad4. It has effect on cellular differentiation PMID: 15881652
    12. expression of TSC-22 in prostate is restricted to basal layer; maybe useful marker for differentation between normal and malignant acinar epithelium of prostate PMID: 16106424
    13. TSC-22 is a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD PMID: 17690703
    14. Expression of TSC-22 was frequently observed in the tumor cells with differentiated-phenotypes, although rarely in the cells with growing potentials. PMID: 18288391
    15. interaction between fortilin and TSC-22 prevents apoptosis via the destabilization of TSC-22 in ovarian carcinoma cells PMID: 18325344

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    TSC-22/Dip/Bun family
  • 组织特异性：
    Widely expressed in fetal and adult tissues.
  • 数据库链接：

    HGNC: 16826

    OMIM: 607715

    KEGG: hsa:8848

    STRING: 9606.ENSP00000397435

    UniGene: Hs.436383