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ZFP91 Antibody

  • 中文名称：
    ZFP91兔多克隆抗体
  • 货号：
    CSB-PA504466
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of hepg2, NT28 cells using Antibody diluted at 500. Secondary antibody was diluted at 1:20000
  • 其他：

产品详情

  • Uniprot No.：
    Q96JP5
  • 基因名：
    ZFP91
  • 别名：
    ZFP91 antibody; ZNF757 antibody; FKSG11E3 ubiquitin-protein ligase ZFP91 antibody; EC 2.3.2.27 antibody; RING-type E3 ubiquitin transferase ZFP91 antibody; Zinc finger protein 757 antibody; Zinc finger protein 91 homolog antibody; Zfp-91 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 401-450
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-10000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.
  • 基因功能参考文献：
    1. lenalidomide induces the ubiquitination and degradation of ZFP91 PMID: 28530236
    2. Data show that NF-kappaB/p65 is required for the binding of zinc finger protein 91 (ZFP91) to the HIF-1alpha promoter and for the transcriptional activation of HIF-1alpha gene mediated by ZFP91. PMID: 27144516
    3. ZFP91 is overexpressed in prostate cancer. PMID: 27975057
    4. hHgher protein levels of ZFP91 in all cancer cell lines. PMID: 24272675
    5. These data clearly indicate that ZFP91 is a key regulator in LIGHT-induced activation of non-canonical NF-kappaB pathway in LTbetaR signaling. PMID: 20804734
    6. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. PMID: 20682767
    7. likely to play an important role in cell proliferation and/or anti-apoptosis, and may serve as a molecular marker for AML PMID: 12738986

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.
  • 数据库链接：

    HGNC: 14983

    KEGG: hsa:80829

    STRING: 9606.ENSP00000339030

    UniGene: Hs.524920