BAG3
BAG3，即Bcl2相关永生基因3，别名CAIR-1/Bis/MFM6。它是一种由人类BAG3基因编码的蛋白质，属于BAG家族蛋白。BAG3在多种细胞过程中发挥作用，包括细胞凋亡、发育、细胞骨架组织和自噬。其作用机制涉及与热休克蛋白70(Hsp70)的ATP酶结构域相互作用，通过BAG结构域，以及与其他蛋白质的相互作用，如通过WW结构域和PXXP结构域。BAG3通过调节这些途径，介导细胞对应激刺激的适应性反应，其表达失调可能导致多种肿瘤的发生。BAG3还与扩张型心肌病(DCM)相关，其基因突变可能是DCM的新病因。
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验证数据
Western blot analysis of extracts from 293 cells, using BAG3 antibody.
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using BAG3 antibody.
BAG3 Antibodies
BAG3 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA002531GA01HU | BAG3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA644586 | BAG3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA006106 | BAG3 Antibody | Human | WB, ELISA |
| CSB-PA080018 | BAG3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA056537 | BAG3 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA245428 | BAG3 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-RA002531A0HU | BAG3 Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
| CSB-PA002531LA01HU | BAG3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA002531LB01HU | BAG3 Antibody,HRP conjugated | Human | ELISA |
| CSB-PA002531LC01HU | BAG3 Antibody，FITC conjugated | Human |
BAG3 Proteins
BAG3 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP002531HU CSB-EP002531HU CSB-BP002531HU CSB-MP002531HU CSB-EP002531HU-B |
Recombinant Human BAG family molecular chaperone regulator 3 (BAG3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
