Map2k2
MAP2K2，即丝裂原活化蛋白激酶激酶2，别名MEK2、MKK2等。它是一种双特异性蛋白激酶，属于MAP激酶激酶家族成员，由人体细胞自身的基因编码。MAP2K2在细胞的增殖、分化、细胞粘附和转录等多种生物学过程中发挥着重要作用。其作用机制主要是通过接受上游RAF激酶的磷酸化激活信号，进而对下游的ERK1/2（胞外信号调节激酶1/2）进行磷酸化，从而激活ERK1/2作为转录调节因子 。MAP2K2在生物学上的意义非常重大，它参与调控的信号通路是细胞增殖、应激、炎症、分化、功能同步化、转化、凋亡等信号转导通路的共同交汇通路之一。MAP2K2的活性对于细胞对多种生长因子、细胞因子、射线、渗透压等刺激的响应至关重要。此外，MAP2K2的异常激活与多种癌症的发生发展有关，其抑制或降解也参与了某些病原体如耶尔森菌和炭疽的致病机制 。
热销产品
MAP2K2 Antibody (CSB-PA04909A0Rb)
验证数据
Western Blot
Positive WB detected in: HL60 whole cell lysate
All lanes: MAP2K2 antibody at 2.8µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45 kDa
Observed band size: 45 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA04909A0Rb at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA04909A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Map2k2 Antibodies
Map2k2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA013411GA01HU | MAP2K2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA062510 | Phospho-MAP2K2 (Thr394) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA898246 | MAP2K2 (Ab-394) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000570 | Phospho-MAP2K2 (T394) Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA030302 | MAP2K2 Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA080229 | MAP2K2 Antibody | Human,Mouse,Rat | WB, IHC |
| CSB-PA097880 | MAP2K2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA224661 | MAP2K2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA04909A0Rb | MAP2K2 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA04909C0Rb | MAP2K2 Antibody, FITC conjugated | Human | |
| CSB-PA04909D0Rb | MAP2K2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA101222 | MAP2K2 Antibody | Human | WB, IHC, ELISA |
| CSB-MA671424 | MAP2K2 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF,IP |
Map2k2 Proteins
Map2k2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013411HU CSB-EP013411HU CSB-BP013411HU CSB-MP013411HU CSB-EP013411HU-B |
Recombinant Human Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Map2k2 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013411RA CSB-EP013411RA CSB-BP013411RA CSB-MP013411RA CSB-EP013411RA-B |
Recombinant Rat Dual specificity mitogen-activated protein kinase kinase 2 (Map2k2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Map2k2 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP626627DO CSB-EP626627DO CSB-BP626627DO CSB-MP626627DO CSB-EP626627DO-B |
Recombinant Dog Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Map2k2 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP723614MO CSB-EP723614MO CSB-BP723614MO CSB-MP723614MO CSB-EP723614MO-B |
Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 2 (Map2k2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Map2k2 Proteins for Cyprinus carpio (Common carp)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP835446EQE CSB-EP835446EQE CSB-BP835446EQE CSB-MP835446EQE CSB-EP835446EQE-B |
Recombinant Cyprinus carpio Dual specificity mitogen-activated protein kinase kinase 2 (map2k2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Map2k2 Proteins for Gallus gallus (Chicken)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP838569CH CSB-EP838569CH CSB-BP838569CH CSB-MP838569CH CSB-EP838569CH-B |
Recombinant Chicken Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
