P4HA2
P4HA2，即脯氨酰4-羟化酶亚基2，别名包括 2-oxoglutarate-4-dioxygenase subunit alpha-2、4 PH alpha 2、4-PH alpha-2、C-P4Halpha(II)。它是一种由P4HA2基因编码的蛋白质，属于脯氨酰4-羟化酶的α亚基，是胶原蛋白合成的关键酶之一。P4HA2的作用机制主要是催化胶原蛋白前体链中脯氨酸残基的4-羟化，这一过程对于胶原蛋白的正确三螺旋结构形成至关重要。P4HA2参与了细胞外基质的重塑，影响肿瘤细胞的极性、运动和信号转导。P4HA2的表达与多种实体肿瘤的侵袭、转移密切相关，并且可以调控肿瘤相关基因表达、增强肿瘤细胞恶性表型表达及耐药性形成。在肿瘤微环境中，P4HA2通过促进胶原蛋白沉积与硬化重塑肿瘤微环境，进而促进肿瘤进展。此外，P4HA2还通过调节细胞代谢、促进肿瘤起始细胞存活、参与血管基底膜生成及调控肿瘤相关基因表达等多种作用机制促进肿瘤细胞增殖、黏附和转移。
热销产品
P4HA2 Antibody (CSB-PA017340ESR2HU)
验证数据
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA017340ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA017340ESR2HU at dilution of 1:100
Immunoprecipitating P4HA2 in Hela whole cell lysate
Lane 1: Rabbit control IgG instead of (1μg) instead of CSB-PA017340ESR2HU in Hela whole cell lysate.
For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: CSB-PA017340ESR2HU (4μg) + Hela whole cell lysate (500μg)
Lane 3: Hela whole cell lysate (20μg)
P4HA2 Antibodies
P4HA2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA017340GA01HU | P4HA2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA017340ESR1HU | P4HA2 Antibody | Human | ELISA, WB, IHC, IP |
| CSB-PA017340ESR2HU | P4HA2 Antibody | Human | ELISA, IHC, IP |
P4HA2 Proteins
P4HA2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP017340HU CSB-EP017340HU CSB-BP017340HU CSB-MP017340HU CSB-EP017340HU-B |
Recombinant Human Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
