PLXNB2
PLXNB2，即神经丛蛋白B2，别名KIAA0315、MM1、Nbla00445、PLEXB2等。它是一种跨膜受体，参与轴突导向和细胞迁移，响应于信号蛋白如血管生成素。PLXNB2的作用机制包括与血管生成素结合，激活下游的RHOA信号通路，影响细胞骨架的重组和细胞迁移。PLXNB2在神经系统发育、肿瘤发生发展、以及细胞迁移和增殖等过程中发挥重要作用。例如，它在急性髓系白血病（AML）中的过表达与不良预后相关，可能作为潜在的生物标志物和治疗靶点。此外，PLXNB2还与癌症肝转移的形成有关，其在肝细胞中的表达增加可以促进肠癌、胰腺癌和黑色素瘤等癌症的肝转移。
热销产品
Recombinant Human Plexin-B2 (PLXNB2), partial (CSB-EP018223HUe1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
PLXNB2 Antibody (CSB-PA018223ESR1HU)
验证数据
Western blot
All lanes: PLXNB2 antibody IgG at 2.39μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 205 kDa
Observed band size: 205 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA018223ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA018223ESR1HU at dilution of 1:100
PLXNB2 Antibodies
PLXNB2 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA018223GA01HU | PLXNB2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA124601 | PLXNB2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA347467 | PLXNB2 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA018223ESR1HU | PLXNB2 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA018223LA01HU | PLXNB2 Antibody | Human | ELISA, WB |
| CSB-PA018223LB01HU | PLXNB2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA018223LC01HU | PLXNB2 Antibody，FITC conjugated | Human | |
| CSB-PA018223LD01HU | PLXNB2 Antibody， Biotin conjugated | Human | ELISA |
PLXNB2 Proteins
PLXNB2 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP018223HU CSB-EP018223HU CSB-BP018223HU CSB-MP018223HU CSB-EP018223HU-B |
Recombinant Human Plexin-B2 (PLXNB2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP018223HUe1 | Recombinant Human Plexin-B2 (PLXNB2), partial | E.coli |
