前列腺癌
前列腺癌是男性生殖系统中最常见的恶性肿瘤之一,尤其在65岁及以上的男性群体里更为常见。前列腺癌的生长速度通常较慢,许多患者在一生中可能不会因前列腺癌而受到影响。然而,对于晚期或转移性前列腺癌,治疗选择有限,预后较差。
治疗前列腺癌的方法包括手术、放疗、化疗、激素治疗等。近年来,前列腺癌的治疗领域取得了显著进展,特别是在靶向治疗和免疫治疗方面。例如,雄激素受体抑制剂如恩扎卢胺(enzalutamide)等药物的研发和应用,为晚期前列腺癌患者提供了新的治疗选择。此外,针对程序性死亡受体(PD-1)或程序性死亡配体(PD-L1)信号通路的免疫检查点阻断疗法,也在治疗前列腺癌方面显示出潜力。
最新的研究还发现,分泌蛋白Gremlin1作为FGFR1的新型配体,通过FGFR1/MAPK信号通路调控肿瘤细胞可塑性,促进去势抵抗性前列腺癌(CRPC)的发生发展。这为靶向治疗CRPC提供了新的候选药物和治疗策略。
前列腺癌药物靶点
前列腺癌药物靶点相关产品推荐
● 靶点蛋白
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP007763HU
Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.
CSB-MP006163HU1
Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.
CSB-MP878942HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP733578HU
Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC50 of human CD276 protein is 1.961-2.243 ng/ml.
CSB-MP004939HU
Measured by its binding ability in a functional ELISA. Immobilized CD46 at 2 μg/ml can bind Anti-CD46 rabbit monoclonal antibody, the EC50 of human CD46 protein is 0.8333-1.054 ng/ml.
CSB-MP723415HU
Measured by its binding ability in a functional ELISA. Immobilized DLL3 at 2 μg/ml can bind Anti-DLL3 Recombinant Antibody (CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.
CSB-MP882142HU
Measured by its binding ability in a functional ELISA. Immobilized DLL3 at 2 μg/ml can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.
● 稳定细胞株
HEK293F/Human DLL3 Stable Cell Line
CSB-SC882142HU
Untransfected HEK293 cells (green line) and transfected Human DLL3 HEK293 stable cells (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.
● 重组抗体
CSB-RA878942MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
CSB-RA004936MA1HU
Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.
CSB-RA006163MA1HU
Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.
CSB-RA159341A0HU
Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CDH6 Recombinant Monoclonal Antibody | CSB-RA005055MA1HU | CDH6 | Human | ELISA |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA260392A0HU | ERBB2 | Human | ELISA, IHC, IF |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA1HU | ERBB2 | Human | ELISA |
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody | CSB-RA588766A0HU | ERBB2 | Human | ELISA, IHC, IF |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA2HU | ERBB2 | Human | ELISA, IHC |
FGFR3 Recombinant Monoclonal Antibody | CSB-RA555849A0HU | FGFR3 | Human | ELISA, IF |
FGFR3 Recombinant Monoclonal Antibody | CSB-RA966627A0HU | FGFR3 | Human | ELISA, WB |
IFNAR1 Recombinant Monoclonal Antibody | CSB-RA011046A0HU | IFNAR1 | Human | ELISA |