免疫类疾病(免疫紊乱)
免疫系统是人体抵御外来病原体、维持内部稳定的重要系统。免疫紊乱是指人体免疫系统功能失调的状态,这种失调可能是由于遗传、环境、生活方式等多种因素引起的,可能会导致多种疾病。免疫紊乱可以分为两大类:免疫缺陷和自身免疫疾病。
- 免疫缺陷:是指免疫系统功能低下,无法有效抵御外来病原体的侵害。免疫缺陷可能是先天性的,如先天性免疫缺陷病;也可能是后天性的,如艾滋病、长期使用免疫抑制剂等。免疫缺陷会导致患者容易感染、疾病恢复缓慢等问题。
- 自身免疫疾病:是指免疫系统错误地攻击自身组织,导致组织损伤和功能障碍。常见的自身免疫疾病包括类风湿关节炎、系统性红斑狼疮、甲状腺疾病等。
免疫缺陷和自身免疫疾病是两类重要的免疫相关疾病,近年来在药物研发方面取得了显著进展:
- 针对免疫缺陷的药物研发:leniolisib是一种口服选择性磷脂酰肌醇3-激酶δ(PI3Kδ)抑制剂,已被美国食品和药物管理局(FDA)受理进行优先审查,用于治疗活化的肌醇磷脂3-激酶δ综合征(APDS),这是一种罕见的原发性免疫缺陷病。这表明针对特定免疫缺陷病的精准治疗策略正在逐步实现。
- 针对自身免疫疾病的药物研发:自身免疫性疾病的治疗药物包括传统的合成抗风湿药(DMARDs),如激素、免疫抑制剂、免疫调节剂和抗炎药物。近年来,生物制剂和靶向DMARDs的研发取得了显著进展,例如大分子单克隆抗体(如英夫利昔单抗、托珠单抗)和JAK抑制剂(如托法替尼、巴瑞特尼)。
此外,细胞因子类药物通过调节免疫反应在治疗免疫缺陷和自身免疫疾病中具有重要作用。例如,通过PEG化增加IL-2半衰期的药物NKTR-214,以及通过融合技术增加细胞因子靶向特异性的药物,如ALT-803(IL-15“超级激动剂”复合物)。抗体融合细胞因子,如IL-2、TNF、IL-15等,通过特定的抗体导向技术,将细胞因子定向输送到疾病部位,以提高治疗效果和减少副作用。
免疫类疾病药物靶点
- ALB
- APP
- ASN1
- asnA
- BTLA
- C1R
- C1S
- C3
- C5
- CCR5
- CCR7
- CD19
- CD2
- CD200R1
- CD22
- CD247
- CD274
- CD28
- CD33
- CD34
- CD37
- CD38
- CD3E
- CD4
- CD40
- CD40LG
- CD44
- CD47
- CD52
- CD6
- CD7
- CD70
- CD79B
- CD80
- CD86
- CSF1R
- CSF2
- CSF2RA
- CSF3R
- CTLA4
- CXCL13
- CXCR4
- CXCR5
- DNA2
- DRD4
- EGFR
- EpoR
- ERBB2
- FCER1A
- FCER2
- FCGR1A
- FCGR2B
- FCGR3A
- FCGRT
- FN1
- GCGR
- GHR
- GLP1R
- GP41
- GPRC5D
- HAVCR2
- HLA-DRA
- ICAM1
- ICOS
- IFNAR1
- IFNAR1
- IFNB1
- IFNGR1
- IGF1R
- IL10RA
- IL12A
- IL12RB1
- IL13
- IL15
- IL15RA
- IL17A
- IL17A
- IL17F
- IL18
- IL1A
- IL1B
- IL1R1
- IL1RL1
- IL2
- IL21
- IL22RA1
- IL23A
- IL25
- IL2RA
- IL2RA
- IL2RB
- IL2RG
- IL31
- IL33
- IL3RA
- IL3RA
- IL4
- IL4R
- IL5
- IL5RA
- IL6
- IL6R
- IL6ST
- IL7R
- INSR
- ITGA4
- ITGA4
- ITGAL
- KIT
- KLKB1
- LAG3
- MASP2
- MET
- MPL
- MS4A1
- NCR1
- NT5E
- PDCD1
- RHD
- ROR1
- SDC1
- SIRPA
- SLAMF7
- SLC25A21
- SNAP25
- TGFB1
- TIGIT
- TLR3
- TNF
- TNFRSF10B
- TNFRSF13C
- TNFRSF17
- TNFRSF1A
- TNFRSF1B
- TNFRSF4
- TNFRSF8
- TNFSF11
- TNFSF13
- TNFSF13B
- TNFSF4
- TNFSF9
- TOP1
- TSLP
- VEGFA
免疫类疾病药物靶点相关产品推荐
● 靶点蛋白
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP023974HU1
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP004900HU
Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.
CSB-MP878942HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP004940HU
Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.
Measured by its binding ability in a functional ELISA. Immobilized Human IL4 (CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R,the EC50 is 12.68-14.23 ng/mL.
CSB-MP023983HU1
Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml
● 稳定细胞株
CT26/Human ROR1 Stable Cell Line
CSB-SC020067HU
Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重组抗体
CSB-RA303909A0HU
Overlay histogram showing HepG2 cells stained with CSB-RA303909A0HU (red line) at 1:50.
CSB-RA878942MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
CSB-RA919940A0HU
Overlay Peak curve showing 3T3 cells stained with CSB-RA919940A0HU (red line) at 1:50.
CSB-RA983271A0HU
Overlay histogram showing Hela cells stained with CSB-RA983271A0HU (red line) at 1:50.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | ALB | Human | ELISA, FC |
APP Recombinant Monoclonal Antibody | CSB-RA994273A0HU | APP | Human, Mouse, Rat | ELISA, WB, IF |
BTLA Recombinant Monoclonal Antibody | CSB-RA773799MA1HU | BTLA | Human | ELISA, FC |
C3 Recombinant Monoclonal Antibody | CSB-RA303909A0HU | C3 | Human | ELISA, WB, IHC, FC |
C3 Recombinant Monoclonal Antibody | CSB-RA699863A0HU | C3 | Human | ELISA, IHC |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888A0HU | CD19 | Human | ELISA |
CD19 Recombinant Monoclonal Antibody | CSB-RA780821A0HU | CD19 | Human | ELISA, WB, IHC, IP |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888MA1HU | CD19 | Human, Mouse | ELISA, WB |
CD22 Recombinant Monoclonal Antibody | CSB-RA962691A0HU | CD22 | Human | ELISA, IHC |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD34 Recombinant Monoclonal Antibody | CSB-RA004926A0HU | CD34 | Human | ELISA, IHC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD3E Recombinant Monoclonal Antibody | CSB-RA004931MA1HU | CD3E | Human | ELISA, FC |
CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | CD4 | Human | ELISA, WB, IHC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD44 Recombinant Monoclonal Antibody | CSB-RA004938A0HU | CD44 | Human | ELISA, WB, IHC |
CD44 Recombinant Monoclonal Antibody | CSB-RA292372A0HU | CD44 | Human | ELISA, WB, IHC, IF, FC |
● ELISA试剂盒
产品名称 | 货号 | 靶点 | 检测范围 | 灵敏度 |
---|---|---|---|---|
Bovine Albumin(Alb) ELISA kit | CSB-E08664b | ALB | 0.313 μg/mL-80 μg/mL | 0.148 μg/mL |
Mouse Albumin (Alb)ELISA Kit | CSB-E13878m | ALB | 0.781 μg/mL-200 μg/mL | 0.110 μg/mL |
Dog Albumin(Alb) ELISA Kit | CSB-E15757c | ALB | 0.273 μg/mL-35 μg/mL | 0.266 μg/mL |
Sheep Albumin (Alb)ELISA Kit | CSB-E15839Sh | ALB | 350 μg/mL-21.88 μg/mL | 5.5 μg/mL |
Horse Albumin(Alb) ELISA Kit | CSB-E16205Hs | ALB | 1.25 μg/mL-80 μg/mL | 1.247 μg/mL |
Pig Albumin (Alb) ELISA Kit | CSB-E16207p | ALB | 0.03 μg/mL-7000 μg/mL | 0.03 μg/mL |
Goat Albumin (Alb)ELISA Kit | CSB-E15758G | ALB | 0.17 μg/mL-350 μg/mL | 0.17 μg/mL |
Guinea Pig Albumin(Alb) ELISA kit | CSB-E15765Gp | ALB | 0.156 μg/mL-10 μg/mL | 0.09 μg/mL |
Rabbit Albumin(Alb) ELISA Kit | CSB-E16204Rb | ALB | 0.273 μg/mL-70 μg/mL | 0.117 μg/mL |
Rat Amyloid beta A4 protein(APP) ELISA kit | CSB-EL001950RA | APP | 15.6 ng/mL-1000 ng/mL | 3.9 ng/mL |
Human B- and T-lymphocyte attenuator(BTLA) ELISA kit | CSB-EL002868HU | BTLA | 0.45 ng/mL-30 ng/mL | 0.11 ng/mL |
Mouse B- and T-lymphocyte attenuator(BTLA) ELISA kit | CSB-EL002868MO | BTLA | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human Complement C1s subcomponent(C1S) ELISA kit | CSB-EL003657HU | C1S | 25 ng/mL-1600 ng/mL | 6.25 ng/mL |
Human Complement 3,C3 ELISA Kit | CSB-E08665h | C3 | 4.7 ng/mL-300 ng/mL | 4.031 ng/mL |
Pig Complement 3,C3 ELISA Kit | CSB-E06920p | C3 | 0.625 μg/mL-10 μg/mL | 0.625 μg/mL |
Rat Complement 3,C3 ELISA Kit | CSB-E08666r | C3 | 0.625 μg/mL-40 μg/mL | 0.156 μg/mL |
Mouse Complement 3,C3 ELISA Kit | CSB-E08667m | C3 | 93.75 ng/mL-6000 ng/mL | 23.44 ng/mL |
Rabbit Complement 3,C3 ELISA Kit | CSB-E08668Rb | C3 | 27.3 ng/mL-7000 ng/mL | 27.3 ng/mL |
Fish Complement 3,C3 ELISA Kit | CSB-E09727s | C3 | 12.5 μg/mL-500 μg/mL | 12.5 μg/mL |
Monkey Complement 3(C3)ELISA Kit | CSB-E16528Mk | C3 | 4.68 ng/mL-300 ng/mL | 1.17 ng/mL |