皮肤和结缔组织疾病
皮肤和结缔组织疾病是一类影响皮肤、肌肉、骨骼、血管和其他连接组织的疾病。这些疾病可能是由于遗传、免疫异常、环境因素或其他未知因素引起的。一些常见的皮肤和结缔组织疾病包括系统性红斑狼疮(SLE)、类风湿关节炎(RA)、皮肌炎、干燥综合征(SS)、系统性硬化症等。
近年来,皮肤和结缔组织疾病的药物研发正在不断取得进展,部分列举如下:
- Janus激酶(JAK)抑制剂:JAK抑制剂是治疗皮肤病如银屑病和特应性皮炎的新型药物,通过调节细胞信号传导发挥作用。
- 芳香烃受体(AhR)调节剂:AhR是一种转录调控因子,参与多种生理过程,包括免疫调节。AhR调节剂治疗炎症性皮肤病具有独特作用机制,正在成为皮肤病治疗格局的改变者。
- siRNA经皮给药系统:(小干扰RNA)经皮给药系统成为皮肤疾病治疗研究的热点,尤其是针对细胞毒性T淋巴细胞相关抗原-4(CTLA-4)和程序性细胞死亡-1(PD-1)的siRNA抑制剂可用于皮肤黑素瘤的治疗。
皮肤和结缔组织疾病药物靶点
- ALB
- AOC3
- BAFF
- BTLA
- C1R
- C1S
- C5
- CD19
- CD200R1
- CD247
- CD27
- CD274
- CD276
- CD28
- CD38
- CD4
- CD40
- CD40LG
- CD44
- CD47
- CD80
- CD86
- CEACAM5
- COL7A1
- CSF1R
- CSF2
- CSF2RA
- CSF3R
- CTLA4
- CXCL8
- DNA2
- EGFR
- EPOR
- ERBB2
- ERBB3
- FCGR1A
- FCGR2B
- FCGRT
- FGFR3
- FN1
- FOLR1
- GHR
- ICAM1
- ICOS
- IDS
- IDUA
- IFNAR1
- IFNGR1
- IGF1R
- IL10RA
- IL12A
- IL12B
- IL12RB1
- IL13
- IL17A
- IL17F
- IL18
- IL1A
- IL1B
- IL1R1
- IL2
- IL22
- IL23A
- IL2RA
- IL2RB
- IL31
- IL33
- IL4
- IL4R
- IL6
- IL6R
- IL6ST
- ITGAL
- KDR
- KLK5
- KLK7
- KLKB1
- LAG3
- MET
- MS4A1
- MUC1
- NECTIN4
- NGFR
- NT5E
- PDCD1
- PDGFRB
- PRLR
- PTH1R
- ROR1
- SGSH
- SIRPA
- SNAP25
- SOST
- STING1
- TACSTD2
- TGFB1
- TGFBR2
- TIGIT
- TNF
- TNFRSF10B
- TNFRSF1A
- TNFRSF4
- TNFSF11
- TNFSF13
- TNFSF4
- TNFSF9
- TOP1
- TPBG
- TSLP
- VEGFA
- VTCN1
皮肤和结缔组织疾病靶点相关产品推荐
● 靶点蛋白
CSB-MP007763HU
Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-BP624104HU(M)
Measured by its binding ability in a functional ELISA. Immobilized Human IL17A at 2 μg/ml can bind Anti-IL17A recombinant antibody (CSB-RA624104MA1HU), the EC50 is 1.818-2.170 ng/mL.
CSB-MP878942HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP007479HU
Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
Measured by its binding ability in a functional ELISA. Immobilized Human IL4 (CSB-MP011659HU) at 2μg/mL can bind biotinylated Human IL4R,the EC50 is 12.68-14.23 ng/mL.
CSB-MP023072HU1
Measured in cell activity assay using U937 cells, the EC50 for this effect is 190.2-298.6 ng/ml.
● 稳定细胞株
CT26/Human ROR1 Stable Cell Line
CSB-SC020067HU
Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重组抗体
CSB-RA264109A0HU
Overlay Peak curve showing HepG2 cells stained with CSB-RA264109A0HU (red line) at 1:50.
CSB-RA773799MA1HU
Untransfected HEK293T cells (green line) and transfected Human ENPP3 HEK293T Stable cells (red line) were stained with anti-ENPP3 antibody (2µg/1*106 cells).
CSB-RA003995MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA003995MA1HU (red line) at 1:800.
CSB-RA878942MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | ALB | Human | ELISA, FC |
BTLA Recombinant Monoclonal Antibody | CSB-RA773799MA1HU | BTLA | Human | ELISA, FC |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888A0HU | CD19 | Human | ELISA |
CD19 Recombinant Monoclonal Antibody | CSB-RA780821A0HU | CD19 | Human | ELISA, WB, IHC, IP |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888MA1HU | CD19 | Human, Mouse | ELISA, WB |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD27 Recombinant Monoclonal Antibody | CSB-RA953976A0HU | CD27 | Human | ELISA, WB |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | CD4 | Human | ELISA, WB, IHC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD44 Recombinant Monoclonal Antibody | CSB-RA004938A0HU | CD44 | Human | ELISA, WB, IHC |
CD44 Recombinant Monoclonal Antibody | CSB-RA292372A0HU | CD44 | Human | ELISA, WB, IHC, IF, FC |
CD44 Recombinant Monoclonal Antibody | CSB-RA004938MA1HU | CD44 | Human | ELISA, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CD80 Recombinant Monoclonal Antibody | CSB-RA246383A0HU | CD80 | Human | ELISA, WB, IHC, IP |
CD86 Recombinant Monoclonal Antibody | CSB-RA004965A0HU | CD86 | Human | ELISA, WB |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA3HU | CEACAM5 | Human | ELISA, IF, FC |
● ELISA试剂盒
产品名称 | 货号 | 靶点 | 检测范围 | 灵敏度 |
---|---|---|---|---|
Bovine Albumin(Alb) ELISA kit | CSB-E08664b | ALB | 0.313 μg/mL-80 μg/mL | 0.148 μg/mL |
Mouse Albumin (Alb)ELISA Kit | CSB-E13878m | ALB | 0.781 μg/mL-200 μg/mL | 0.110 μg/mL |
Dog Albumin(Alb) ELISA Kit | CSB-E15757c | ALB | 0.273 μg/mL-35 μg/mL | 0.266 μg/mL |
Sheep Albumin (Alb)ELISA Kit | CSB-E15839Sh | ALB | 350 μg/mL-21.88 μg/mL | 5.5 μg/mL |
Horse Albumin(Alb) ELISA Kit | CSB-E16205Hs | ALB | 1.25 μg/mL-80 μg/mL | 1.247 μg/mL |
Pig Albumin (Alb) ELISA Kit | CSB-E16207p | ALB | 0.03 μg/mL-7000 μg/mL | 0.03 μg/mL |
Goat Albumin (Alb)ELISA Kit | CSB-E15758G | ALB | 0.17 μg/mL-350 μg/mL | 0.17 μg/mL |
Guinea Pig Albumin(Alb) ELISA kit | CSB-E15765Gp | ALB | 0.156 μg/mL-10 μg/mL | 0.09 μg/mL |
Rabbit Albumin(Alb) ELISA Kit | CSB-E16204Rb | ALB | 0.273 μg/mL-70 μg/mL | 0.117 μg/mL |
Mouse Membrane primary amine oxidase(AOC3) ELISA kit | CSB-EL001855MO | AOC3 | 1.25 ng/mL-80 ng/mL | 0.31 ng/mL |
Rat Membrane primary amine oxidase(AOC3) ELISA kit | CSB-EL001855RA | AOC3 | 7.8 ng/mL-500 ng/mL | 1.95 ng/mL |
Human B- and T-lymphocyte attenuator(BTLA) ELISA kit | CSB-EL002868HU | BTLA | 0.45 ng/mL-30 ng/mL | 0.11 ng/mL |
Mouse B- and T-lymphocyte attenuator(BTLA) ELISA kit | CSB-EL002868MO | BTLA | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human Complement C1s subcomponent(C1S) ELISA kit | CSB-EL003657HU | C1S | 25 ng/mL-1600 ng/mL | 6.25 ng/mL |
Mouse Complement 5,C5 ELISA Kit | CSB-E13802m | C5 | 0.25 ng/mL-16 ng/mL | 0.06 ng/mL |
Rat Complement fragment 5,C5 ELISA Kit | CSB-E14363r | C5 | 9.38 ng/mL-600 ng/mL | 2.34 ng/mL |
Monkey complement C5 (C5) ELISA kit | CSB-EL003995MK | C5 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | CSB-E13644h | CD274 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | CSB-EL004911MO | CD274 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |