肝癌
肝癌是一种发生在肝脏的恶性肿瘤,主要包括肝细胞癌(Hepatocellular carcinoma, HCC)、肝内胆管癌(Intrahepatic cholangiocarcinoma, ICC)和混合型肝细胞癌-胆管癌(Combined hepatocellular-cholangiocarcinoma, cHCC-CCA)等类型。
肝癌的发病原因多样,常见的风险因素包括乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)感染、过度饮酒、非酒精性脂肪性肝炎、肝硬化以及其他原因引起的慢性肝病。肝癌的早期症状较为隐匿,但随着病情进展,可能出现腹痛、腹部肿胀、黄疸、体重下降等症状。
肝癌常用的治疗手段包括手术切除、肝移植、局部消融治疗、经动脉化疗栓塞(Transarterial chemoembolization, TACE)、放射治疗、系统抗肿瘤治疗等。近年来,随着对肝癌生物学认识的深入和治疗技术的进步,肝癌的药物研发也取得了显著进展,如:
- 分子靶向治疗:多纳非尼(Sorafenib)、仑伐替尼(Lenvatinib)等多激酶抑制剂在肝癌治疗中显示出较好的疗效,能够抑制肿瘤生长和血管生成。
- 免疫治疗:免疫检查点抑制剂如纳武利尤单抗(Nivolumab)和帕博利珠单抗(Pembrolizumab)等已在肝癌治疗中显示出潜力,通过激活患者自身的免疫系统来攻击肿瘤细胞。
- 联合治疗:将免疫治疗药物与血管生成抑制剂或其他药物联合使用,如阿特珠单抗(Atezolizumab)与贝伐珠单抗(Bevacizumab)的联合治疗,已被证实能显著延长患者的生存期。
肝癌药物靶点
肝癌药物靶点相关产品推荐
● 靶点蛋白
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP009705HU(M)
Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.
CSB-MP004900HU
Measured by its binding ability in a functional ELISA. Immobilized human GPC3 (G537R) at 5 μg/ml can bind Anti-GPC3 recombinant antibody, the EC50 is 4.739-7.092 ng/ml.
CSB-MP878942HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP007479HU
Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
CSB-MP675446HU
HFACS assay shows that Human TIGIT can bind to 293F cell overexpressing human CD155.
Measured by its binding ability in a functional ELISA. Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC50 is 2.379-3.094 ng/ml.
CSB-MP007765HU
Measured by its binding ability in a functional ELISA. Immobilized NRG1 (CSB-MP016077HU1(F6)) at 2 μg/ml can bind human ERBB3, the EC50 is 12.32-15.74 ng/ml.
● 稳定细胞株
CT26/Human GPC3 Stable Cell Line
CSB-SC009705HU2
Untransfected CT26 cells (green line) and transfected Human GPC3 CT26 Stable cells (red line) were stained with anti-GPC3 antibody(CSB-RA009705A1HU) (2µg/1*106 cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重组抗体
CSB-RA878942MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
CSB-RA006163MA1HU
Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.
CSB-RA792129A0HU
Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.
CSB-RA024077MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA024077MA1HU (red line) at 1:100.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
ACVRL1 Recombinant Monoclonal Antibody | CSB-RA555022A0HU | ACVRL1 | Human | ELISA, WB, IHC |
ACVRL1 Recombinant Monoclonal Antibody | CSB-RA001262MA1HU | ACVRL1 | Human | ELISA |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA3HU | CEACAM5 | Human | ELISA, IF, FC |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA1HU | CEACAM5 | Human | ELISA |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
EPCAM Recombinant Monoclonal Antibody | CSB-RA932207A0HU | EPCAM | Human | ELISA, WB |
EPCAM Recombinant Monoclonal Antibody | CSB-RA439934A0HU | EPCAM | Human | ELISA, WB, IHC |
EPCAM Recombinant Monoclonal Antibody | CSB-RA007717MA1HU | EPCAM | Human | ELISA, IHC, FC |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA260392A0HU | ERBB2 | Human | ELISA, IHC, IF |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA1HU | ERBB2 | Human | ELISA |
● ELISA试剂盒
产品名称 | 货号 | 靶点 | 检测范围 | 灵敏度 |
---|---|---|---|---|
Human Alpha-fetoprotein,AFP ELISA Kit | CSB-E04770h | AFP | 1.563 ng/mL-100 ng/mL | 1.332 ng/mL |
Mouse Alpha-fetoprotein,AFP ELISA Kit | CSB-E08282m | AFP | 1.23 ng/ml-900 ng/ml. | 1.23 ng/ml. |
Rat Alpha-fetoprotein,AFP ELISA Kit | CSB-E08281r | AFP | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Pig Alpha-fetoprotein(AFP) ELISA kit | CSB-EL001421PI | AFP | 3.12 ng/mL-200 ng/mL | 0.78 ng/mL |
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | CSB-E13644h | CD274 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | CSB-EL004911MO | CD274 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | CSB-EL004936MO | CD40 | Request Information | Request Information |
Human carcinoembryonic antigen,CEA ELISA Kit | CSB-E04767h | CEACAM5 | 5 ng/mL-120 ng/mL | 2 ng/mL |
Mouse carcinoembryonic antign,CEA ELISA Kit | CSB-E13925m | CEACAM5 | 62.5 pg/mL-4000 pg/mL | 15.6 pg/mL |
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit | CSB-E09171h | CTLA4 | 125 pg/mL-8000 pg/mL | 31.25 pg/mL |
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit | CSB-E13637m | CTLA4 | 0.312 ng/mL-20 ng/mL | 0.078 ng/mL |
Mouse Protein delta homolog 1(DLK1) ELISA kit | CSB-EL006945MO | DLK1 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Human epidermal growth factor receptor,EGFR ELISA Kit | CSB-E12124h | EGFR | 0.312 ng/mL-20 ng/mL | 0.019 ng/mL |
Human Epithelial cell adhesion molecule(EPCAM) ELISA kit | CSB-EL007717HU | EPCAM | 0.625 ng/ml-40 ng/ml | 0.156 ng/ml |
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit | CSB-E11161h | ERBB2 | 0.156 ng/mL-10 ng/mL | 0.04 ng/mL |
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit | CSB-EL007765HU | ERBB3 | 125 pg/mL-8000 pg/mL | 31.25 pg/mL |
Human Fibroblast growth factor receptor 3(FGFR3) ELISA kit | CSB-EL008646HU | FGFR3 | 62.5 pg/mL-4000 pg/mL | 15.6 pg/mL |
Human Glypican-3,GPC-3 ELISA Kit | CSB-E11333h | GPC3 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Mouse Glypican-3(GPC-3)ELISA Kit | CSB-E15877m | GPC3 | 3.12 ng/mL-200 ng/mL | 0.78 ng/mL |