男性泌尿生殖器疾病
男性泌尿生殖器疾病包括多种影响男性生殖系统和泌尿系统的健康问题。这些疾病可能包括但不限于前列腺炎、前列腺增生、勃起功能障碍、睾丸炎、附睾炎、阴茎炎、尿路感染以及男性不育等。针对这些疾病,药物研发涉及多个方面,包括病因治疗、症状缓解和预防并发症等。
目前男性泌尿生殖器疾病药物研发主要集中在以下靶点:
- EZH2:是一种组蛋白甲基转移酶,在多种癌症中高表达,促进癌症发生和恶变。他泽司他(Tazemetostat)是一种EZH2抑制剂,能够通过激活免疫系统来抑制膀胱癌,这为表观遗传药物在膀胱癌治疗中的应用提供了新的方向。
- KLK2:KLK2在前列腺癌中高度富集,JNJ-78278343是一种针对KLK2的候选药物,正在开发用于治疗转移性去势抵抗性前列腺癌(mCRPC)。
- PSMA(前列腺特异性膜抗原):PSMA在前列腺癌细胞中高度表达,是前列腺癌治疗和成像的潜在靶点。针对PSMA的药物,包括一些新型的放射性配体疗法,正在开发中。
- AR(雄激素受体):雄激素受体在前列腺癌的发展中起关键作用,因此是内分泌治疗的重要靶点。新型的AR拮抗剂和降解剂正在研发中,以提高治疗效果。
- PARP(多聚ADP-核糖聚合酶):PARP抑制剂在治疗转移性去势抵抗性前列腺癌(mCRPC)中显示出潜力,它们通过抑制DNA修复机制来增强癌细胞对放疗和某些化疗药物的敏感性。
- VEGF(血管内皮生长因子):VEGF在多种肿瘤的血管生成中起关键作用,靶向VEGF的药物如贝伐珠单抗(Bevacizumab)已用于多种癌症的治疗,包括某些泌尿生殖系统肿瘤。
- HER2:HER2在某些前列腺癌患者中过表达,针对HER2的抗体药物偶联物(ADCs)正在开发中。
- c-MET:c-MET是一个酪氨酸激酶受体,在某些泌尿生殖系统肿瘤中过表达,可能成为治疗的靶点。
男性泌尿生殖器疾病药物靶点
- ALB
- ANGPT2
- BAFF
- BTLA
- C1S
- C3
- C5
- CA9
- CCR2
- CD19
- CD247
- CD27
- CD274
- CD276
- CD28
- CD38
- CD3E
- CD40
- CD40LG
- CD46
- CD47
- CD52
- CD70
- CD80
- CD86
- CDH6
- CLDN6
- CSF1R
- CSF2RA
- CSF3R
- CTAG1A
- CTLA4
- DKK1
- DLL3
- DNA2
- EGFR
- ENG
- ENPP3
- ENTPD1
- EPCAM
- EPOR
- ERBB2
- ERBB3
- FCGR1A
- FCGRT
- FGFR3
- FLT3
- FOLH1
- FSHR
- GDF15
- GHR
- GLP1R
- GLP2R
- ICOS
- IFNAR1
- IFNGR1
- IGF1R
- IL10RA
- IL12A
- IL12RB1
- IL15
- IL15RA
- IL17A
- IL1B
- IL1R1
- IL2
- IL2RA
- IL2RB
- IL2RG
- IL4R
- IL6
- IL6R
- IL6ST
- IL7R
- INSR
- KLK2
- LAG3
- LHCGR
- LILRB2
- MAGEA3
- MASP2
- MET
- MS4A1
- MUC1
- NECTIN4
- NPEPPS
- NT5E
- PDCD1
- PGF
- PSCA
- PTH1R
- ROR1
- SELP
- SNAP25
- STEAP1
- STING1
- TACSTD2
- TF
- TGFB1
- TGFB2
- TIGIT
- TK
- TNF
- TNFRSF13C
- TNFRSF17
- TNFRSF1A
- TNFRSF4
- TNFSF13
- TNFSF9
- TOP1
- TP53
- TPBG
- VEGFA
- VEGFB
男性泌尿生殖器疾病靶点相关产品推荐
● 靶点蛋白
CSB-MP619964HU1
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Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP006163HU1
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Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.
CSB-MP011649HU3
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Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.
CSB-MP878942HU1
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Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
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Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.
CSB-MP007763HU
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Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.
CSB-MP007479HU
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Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
CSB-MP004954HU1
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Measured by its binding ability in a functional ELISA. Immobilized Human CD70 at 2 μg/ml can bind Anti-CD70 antibody, the EC50 is 2.414-3.196 ng/mL.
● 稳定细胞株
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HEK293T/Human CLDN6 Stable Cell Line
CSB-SC007681HU
Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
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CT26/Human ROR1 Stable Cell Line
CSB-SC020067HU
Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
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HEK293T/Human ENPP3 Stable Cell Line
CSB-SC007681HU
Untransfected HEK293T cells (green line) and transfected Human ENPP3 HEK293T Stable cells (red line) were stained with anti-ENPP3 antibody (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
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HEK293F/Human DLL3 Stable Cell Line
CSB-SC882142HU
Untransfected HEK293 cells (green line) and transfected Human DLL3 HEK293 stable cells (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.
● 重组抗体
CSB-RA244537A0HU
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Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.
CSB-RA006163MA1HU
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Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.
CSB-RA878942MA1HU
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Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
CSB-RA159341A0HU
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Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | ALB | Human | ELISA, FC |
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA191985A0HU | ANGPT2 | Human | ELISA, IHC |
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA001707MA01HU | ANGPT2 | Human | ELISA |
BTLA Recombinant Monoclonal Antibody | CSB-RA773799MA1HU | BTLA | Human | ELISA, FC |
C3 Recombinant Monoclonal Antibody | CSB-RA303909A0HU | C3 | Human | ELISA, WB, IHC, FC |
C3 Recombinant Monoclonal Antibody | CSB-RA699863A0HU | C3 | Human | ELISA, IHC |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CA9 Recombinant Monoclonal Antibody | CSB-RA614990A0HU | CA9 | Human | ELISA, IHC |
CCR2 Recombinant Monoclonal Antibody | CSB-RA297464A0HU | CCR2 | Human | ELISA, IHC |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888A0HU | CD19 | Human | ELISA |
CD19 Recombinant Monoclonal Antibody | CSB-RA780821A0HU | CD19 | Human | ELISA, WB, IHC, IP |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888MA1HU | CD19 | Human, Mouse | ELISA, WB |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD27 Recombinant Monoclonal Antibody | CSB-RA953976A0HU | CD27 | Human | ELISA, WB |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD3E Recombinant Monoclonal Antibody | CSB-RA004931MA1HU | CD3E | Human | ELISA, FC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD46 Recombinant Monoclonal Antibody | CSB-RA908548A0HU | CD46 | Human | ELISA, WB, IHC |
● ELISA试剂盒
产品名称 | 货号 | 靶点 | 检测范围 | 灵敏度 |
---|---|---|---|---|
Bovine Albumin(Alb) ELISA kit | CSB-E08664b | ALB | 0.313 μg/mL-80 μg/mL | 0.148 μg/mL |
Mouse Albumin (Alb)ELISA Kit | CSB-E13878m | ALB | 0.781 μg/mL-200 μg/mL | 0.110 μg/mL |
Dog Albumin(Alb) ELISA Kit | CSB-E15757c | ALB | 0.273 μg/mL-35 μg/mL | 0.266 μg/mL |
Sheep Albumin (Alb)ELISA Kit | CSB-E15839Sh | ALB | 350 μg/mL-21.88 μg/mL | 5.5 μg/mL |
Horse Albumin(Alb) ELISA Kit | CSB-E16205Hs | ALB | 1.25 μg/mL-80 μg/mL | 1.247 μg/mL |
Pig Albumin (Alb) ELISA Kit | CSB-E16207p | ALB | 0.03 μg/mL-7000 μg/mL | 0.03 μg/mL |
Goat Albumin (Alb)ELISA Kit | CSB-E15758G | ALB | 0.17 μg/mL-350 μg/mL | 0.17 μg/mL |
Guinea Pig Albumin(Alb) ELISA kit | CSB-E15765Gp | ALB | 0.156 μg/mL-10 μg/mL | 0.09 μg/mL |
Rabbit Albumin(Alb) ELISA Kit | CSB-E16204Rb | ALB | 0.273 μg/mL-70 μg/mL | 0.117 μg/mL |
Human Angiopoietin 2,ANG-2 ELISA Kit | CSB-E04500h | ANGPT2 | 39 pg/mL-2500 pg/mL | 9.75 pg/mL |
Rat Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07304r | ANGPT2 | Request Information | Request Information |
Mouse Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07305m | ANGPT2 | 0.156 pg/mL-10 pg/mL | 0.039 pg/mL |
Pig Angiopoietin 2,ANG-2 ELISA Kit | CSB-E08460p | ANGPT2 | 0.94 ng/mL-60 ng/mL | 0.235 ng/mL |
Human B- and T-lymphocyte attenuator(BTLA) ELISA kit | CSB-EL002868HU | BTLA | 0.45 ng/mL-30 ng/mL | 0.11 ng/mL |
Mouse B- and T-lymphocyte attenuator(BTLA) ELISA kit | CSB-EL002868MO | BTLA | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human Complement C1s subcomponent(C1S) ELISA kit | CSB-EL003657HU | C1S | 25 ng/mL-1600 ng/mL | 6.25 ng/mL |
Human Complement 3,C3 ELISA Kit | CSB-E08665h | C3 | 4.7 ng/mL-300 ng/mL | 4.031 ng/mL |
Pig Complement 3,C3 ELISA Kit | CSB-E06920p | C3 | 0.625 μg/mL-10 μg/mL | 0.625 μg/mL |
Rat Complement 3,C3 ELISA Kit | CSB-E08666r | C3 | 0.625 μg/mL-40 μg/mL | 0.156 μg/mL |
Mouse Complement 3,C3 ELISA Kit | CSB-E08667m | C3 | 93.75 ng/mL-6000 ng/mL | 23.44 ng/mL |