淋巴癌
淋巴癌,也称淋巴瘤,是起源于淋巴系统(包括淋巴结和淋巴组织)的恶性肿瘤。淋巴瘤可以分为霍奇金淋巴瘤(HL)和非霍奇金淋巴瘤(NHL)两大类。霍奇金淋巴瘤相对少见,而非霍奇金淋巴瘤则包含多种亚型,且异质性强。
淋巴瘤传统的治疗手段包括化疗、放疗等。近年来,靶向治疗、免疫治疗和CAR-T细胞疗法等新兴治疗方法也在快速发展中。
- 靶向治疗药物:靶向治疗药物主要针对淋巴瘤细胞的特定分子靶点,以减少对正常细胞的损害。例如,BTK抑制剂(如伊布替尼、泽布替尼)和BCL-2抑制剂(如维奈克拉)已在治疗某些类型的非霍奇金淋巴瘤中显示出良好的疗效。
- 抗体药物偶联物(ADCs):ADCs是一类新型靶向治疗药物,由抗体、细胞毒性药物和连接这两个部分的链接子组成。例如,Polatuzumab vedotin(Polivy)已被批准用于治疗弥漫性大B细胞淋巴瘤。
- 免疫治疗:免疫治疗通过激活或抑制患者的免疫系统来攻击淋巴瘤细胞。PD-1/PD-L1抑制剂(如帕博利珠单抗)已经在治疗复发/难治性霍奇金淋巴瘤中显示出疗效。
- CAR-T细胞疗法:CAR-T疗法通过改造患者的T细胞使其能够识别并攻击淋巴瘤细胞。目前,已有多种CAR-T疗法在临床试验中显示出治疗某些复发或难治性淋巴瘤的潜力。
- 双特异性抗体:双特异性抗体能够同时结合淋巴瘤细胞和免疫细胞,促进免疫细胞对淋巴瘤细胞的杀伤。例如,Mosunetuzumab(Mosun)在早期临床试验中显示出对侵袭性和惰性B细胞非霍奇金淋巴瘤的治疗效果。
淋巴癌药物靶点
- CD19
- CD2
- CD22
- CD244
- CD247
- CD274
- CD28
- CD33
- CD37
- CD38
- CD4
- CD40
- CD47
- CD52
- CD6
- CD7
- CD70
- CD79B
- CD80
- CSF1R
- CSF2
- CSF3R
- CTLA4
- DNA2
- DRD4
- EGFR
- ENTPD1
- EpoR
- ERBB2
- FCGR3A
- FN1
- FTL
- HAVCR2
- HLA-DRA
- ICAM1
- IFNAR1
- IFNB1
- Ifngr1
- IGF1R
- IL12A
- IL12RB1
- IL15
- IL15RA
- IL1R1
- IL2
- IL21R
- IL2RA
- IL2RB
- IL3RA
- IL6
- LAG3
- MPL
- MS4A1
- NT5E
- PDCD1
- PGF
- ROR1
- SIRPA
- STING1
- TGFB1
- TIGIT
- TNFRSF10B
- TNFRSF13C
- TNFRSF17
- TNFRSF1A
- TNFRSF1B
- TNFRSF4
- TNFRSF8
- TNFSF13B
- TNFSF9
- TOP1
- TP53
- TRBC1
- VEGFA
淋巴癌药物靶点相关产品推荐
● 靶点蛋白
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP004900HU
Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP878942HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP004940HU
Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.
CSB-MP023983HU1
Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml
CSB-MP023997HU1
Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9 (CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL
CSB-MP011649HU3
Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.
● 稳定细胞株
CT26/Human ROR1 Stable Cell Line
CSB-SC020067HU
Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重组抗体
CSB-RA006163MA1HU
Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.
CSB-RA159341A0HU
Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.
CSB-RA956089A0HU
Overlay Peak curve showing MCF-7 cells stained with CSB-RA956089A0HU (red line) at 1:50.
CSB-RA162789A0HU
Overlay histogram showing Raji cells surface stained with CSB-RA162789A0HU (red line) at 1:50.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
CD19 Recombinant Monoclonal Antibody | CSB-RA004888A0HU | CD19 | Human | ELISA |
CD19 Recombinant Monoclonal Antibody | CSB-RA780821A0HU | CD19 | Human | ELISA, WB, IHC, IP |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888MA1HU | CD19 | Human, Mouse | ELISA, WB |
CD22 Recombinant Monoclonal Antibody | CSB-RA962691A0HU | CD22 | Human | ELISA, IHC |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | CD4 | Human | ELISA, WB, IHC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CD70 Recombinant Monoclonal Antibody | CSB-RA004954MA1HU | CD70 | Human | ELISA |
CD80 Recombinant Monoclonal Antibody | CSB-RA246383A0HU | CD80 | Human | ELISA, WB, IHC, IP |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
● ELISA试剂盒
产品名称 | 货号 | 靶点 | 检测范围 | 灵敏度 |
---|---|---|---|---|
Human Natural killer cell receptor 2B4(CD244) ELISA kit | CSB-EL004903HU | CD244 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | CSB-E13644h | CD274 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | CSB-EL004911MO | CD274 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
Human soluble cluster of differentiation 28,sCD28 ELISA Kit | CSB-E09296h | CD28 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human Myeloid cell surface antigen CD33(CD33) ELISA kit | CSB-EL004925HU | CD33 | 125 pg/mL-8000 pg/mL | 31.25 pg/mL |
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit | CSB-E09884h | CD38 | 0.9 ng/mL-60 ng/mL | 0.225 ng/mL |
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit | CSB-EL004929MO | CD38 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human cluster of differentiation 4,CD4 ELISA Kit | CSB-E08956h | CD4 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Rat cluster of differentiation 4,CD4 ELISA Kit | CSB-E12928r | CD4 | 0.78 U/mL-50 U/mL | 0.195 U/mL |
Chicken Cluster of Differentiation 4(CD4) ELISA Kit | CSB-E13114C | CD4 | 3.125 ng/mL-800 ng/mL | 3.125 ng/mL |
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | CSB-EL004936MO | CD40 | Request Information | Request Information |
Human Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940HU | CD47 | 3.12 pg/mL-200 pg/mL | 0.78 pg/mL |
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940MO | CD47 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Human CAMPATH-1 antigen(CD52) ELISA kit | CSB-EL004943HU | CD52 | 78 ng/mL-5000 ng/mL | 19.5 ng/mL |
Mouse cluster of differentiation 6(CD6) ELISA Kit | CSB-EL004949MO | CD6 | Request Information | Request Information |
Human CD70 antigen(CD70) ELISA kit | CSB-EL004954HU | CD70 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Mouse CD70 antigen(CD70) ELISA kit | CSB-EL004954MO | CD70 | Request Information | Request Information |
Mouse T-lymphocyte activation antigen CD80(CD80) ELISA kit | CSB-EL004959MO | CD80 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Human Soluble Cluster of Differentiation 80 (sCD80) ELISA Kit | CSB-E15768h | CD80 | 125 pg/mL-8000 pg/mL | 31.25 pg/mL |