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结直肠癌

结直肠癌是一种起源于结肠或直肠粘膜上皮细胞的恶性肿瘤,其发病率在全球范围内居高不下,是导致癌症相关死亡的主要原因之一。根据肿瘤的位置,结直肠癌可以分为结肠癌和直肠癌。结肠癌通常起源于结肠的息肉,而直肠癌则多发生在直肠的下段。结直肠癌的症状包括便血、排便习惯改变、腹痛、体重下降等。

结直肠癌的治疗已经从传统的化疗药物发展到针对特定分子靶点的靶向治疗和免疫治疗。以下是一些重要的药物靶点及其相关药物的研发进展:

  • EGFR (表皮生长因子受体):在约10%的结直肠癌中过度表达,针对EGFR的单克隆抗体如西妥昔单抗已被用于治疗某些类型的结直肠癌。
  • RAS (KRAS和NRAS):RAS基因突变在结直肠癌中较为常见,尤其是KRAS突变。近年来,针对KRAS G12C突变的抑制剂如索托拉西布(Sotorasib, AMG510)取得了突破性进展,为携带此突变的患者提供了新的治疗选择。
  • BRAF:BRAF V600E突变是结直肠癌中另一个重要的治疗靶点。BRAF抑制剂如维莫非尼(Vemurafenib)和MEK抑制剂如考比替尼(Cobimetinib)的联合使用,已经在治疗BRAF突变的晚期结直肠癌中显示出较好的疗效2。
  • HER2 (人表皮生长因子受体2):HER2过表达在一部分结直肠癌患者中出现,针对HER2的靶向治疗如图卡替尼(Tucatinib)联合曲妥珠单抗(Trastuzumab)已经获得FDA批准,用于治疗HER2阳性的晚期结直肠癌患者。
  • MSI (微卫星不稳定性):MSI-H或dMMR (错配修复缺陷)的结直肠癌对免疫治疗有较好的反应。免疫检查点抑制剂如帕博利珠单抗(Pembrolizumab)在这类患者中已经显示出显著的疗效。
  • VEGF (血管内皮生长因子):抗VEGF单抗如贝伐珠单抗(Bevacizumab)通过抑制肿瘤血管生成,已经被广泛应用于晚期结直肠癌的治疗。

结直肠癌药物靶点相关产品推荐

● 靶点蛋白

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP009705HU(M) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP005165HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human CEACAM5 at 2μg/mL can bind Anti-CEACAM5 recombinant antibody (CSB-RA005165MA1HU), the EC50 is 0.8955-1.719 ng/mL.

CSB-MP011649HU3 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.

CSB-MP023997HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9(CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL

产品名称 货号 靶点 来源 蛋白标签
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active) CSB-MP733578HU CD276 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human CD44 antigen (CD44), partial (Active) CSB-MP004938HU(F1) CD44 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial, Biotinylated (Active) CSB-MP004938HU(F1)j1-B CD44 Mammalian cell C-terminal mFc-Avi-tagged
Recombinant Macaca fascicularis CD44 antigen (CD44), partial (Active) CSB-MP4290MOV CD44 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) CSB-MP005165HU CEACAM5 Mammalian cell C-terminal 10xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) CSB-MP007765HU ERBB3 Mammalian cell C-terminal hFc-tagged
Recombinant Human Hepatocyte growth factor (HGF) (Active) CSB-AP003681HU HGF Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Interleukin-15 receptor subunit alpha (IL15RA), partial (Active) CSB-AP004551HU IL15RA Mammalian cell C-terminal Fc-tagged
Recombinant Mouse Interleukin-15 receptor subunit alpha (Il15ra), partial (Active) CSB-AP004801MO Il15ra Mammalian cell C-terminal Fc-tagged
Recombinant Human Interleukin-2 protein (IL2) (Active) CSB-AP001691HU IL2 E.Coli Tag-Free

● 重组抗体

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CEACAM5 Recombinant Monoclonal Antibody
CSB-RA005165MA3HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA005165MA3HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

IGF1R Recombinant Monoclonal Antibody
CSB-RA011087MA1HU
CSB-RA011087MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.

产品名称 货号 靶点 反应种属 应用范围
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA3HU CEACAM5 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA1HU CEACAM5 Human ELISA
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
EPCAM Recombinant Monoclonal Antibody CSB-RA932207A0HU EPCAM Human ELISA, WB
EPCAM Recombinant Monoclonal Antibody CSB-RA439934A0HU EPCAM Human ELISA, WB, IHC
EPCAM Recombinant Monoclonal Antibody CSB-RA007717MA1HU EPCAM Human ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody CSB-RA260392A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU ERBB2 Human ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody CSB-RA588766A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA2HU ERBB2 Human ELISA, IHC
ERBB3 Recombinant Monoclonal Antibody CSB-RA937008A0HU ERBB3 Human ELISA, IF
IGF1R Recombinant Monoclonal Antibody CSB-RA011087MA1HU IGF1R Human ELISA, FC
IL2RA Recombinant Monoclonal Antibody CSB-RA011649MA1HU IL2RA Human ELISA, IF
MET Recombinant Monoclonal Antibody CSB-RA983271A0HU MET Human ELISA, WB, IHC, IF, FC
MET Recombinant Monoclonal Antibody CSB-RA634199A0HU MET Human ELISA, IHC
MET Recombinant Monoclonal Antibody CSB-RA013714MA1HU MET Human ELISA, IF, FC
NT5E Recombinant Monoclonal Antibody CSB-RA978310A0HU NT5E Human ELISA, IHC
PDCD1 Recombinant Monoclonal Antibody CSB-RA240597A0HU PDCD1 Human ELISA, WB, IHC
TOP1 Recombinant Monoclonal Antibody CSB-RA792129A0HU TOP1 Human ELISA, WB, IHC, FC, IP

● ELISA试剂盒

产品名称 货号 靶点 检测范围 灵敏度
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit CSB-E14285h CD276 3.12 ng/mL-200 ng/mL 0.78 ng/mL
Human cluster Of differentiation,CD44 ELISA Kit CSB-E11846h CD44 78 pg/mL-5000 pg/mL 19.5 pg/mL
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human carcinoembryonic antigen,CEA ELISA Kit CSB-E04767h CEACAM5 5 ng/mL-120 ng/mL 2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit CSB-E13925m CEACAM5 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Human Delta-like protein 4(DLL4) ELISA kit CSB-EL006949HU DLL4 23.5 pg/mL-1500 pg/mL 5.8 pg/mL
Mouse Delta-like protein 4(DLL4) ELISA kit CSB-EL006949MO DLL4 10 ng/mL-0.16 ng/mL 0.04 ng/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Human Epithelial cell adhesion molecule(EPCAM) ELISA kit CSB-EL007717HU EPCAM 0.625 ng/ml-40 ng/ml 0.156 ng/ml
Human epidermal growth factor receptor 2 (sp185/HER2) ELISA Kit CSB-E11161h ERBB2 0.156 ng/mL-10 ng/mL 0.04 ng/mL
Human Receptor tyrosine-protein kinase erbB-3(ERBB3) ELISA kit CSB-EL007765HU ERBB3 125 pg/mL-8000 pg/mL 31.25 pg/mL
Human growth differentiation factor 15(GDF15)ELISA Kit CSB-E12009h GDF15 7.8 pg/mL-500 pg/mL 1.95 pg/mL
Rat growth differentiation factor 15(GDF15)ELISA Kit CSB-E16317r GDF15 1.56 pg/mL-100 pg/mL 0.39 pg/mL
Mouse Growth/differentiation factor 15(GDF15) ELISA kit CSB-EL009345MO GDF15 7.8 pg/ml -500 pg/ml 1.95 pg/ml