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血液和淋巴疾病

非肿瘤性血液和淋巴疾病包括一系列影响血液成分和淋巴系统功能的状况,如贫血、凝血障碍、血小板异常、骨髓增生异常综合征等。这些疾病的治疗方法多样,包括药物治疗、输血、骨髓移植等。近年来,针对这些非肿瘤性血液和淋巴疾病的药物研发也取得了显著进展。

  • 贫血:贫血是血液中红细胞数量或血红蛋白含量低于正常水平的疾病。治疗贫血的新药物研发主要集中在刺激红细胞生成的药物,如红细胞生成素(erythropoiesis-stimulating agents, ESAs)。ESAs通过模拟内源性红细胞生成素的作用,促进红细胞的产生,用于治疗慢性肾脏病引起的贫血。
  • 凝血障碍:凝血障碍是指血液凝固过程受到影响的疾病,如血友病。在这一领域,新药物的研发主要集中在替代疗法和基因疗法。例如,重组凝血因子的开发为血友病患者提供了有效的替代治疗。此外,基因疗法的研究也在不断进展,旨在通过修复或替换有缺陷的基因来治疗凝血障碍。
  • 血小板异常:血小板异常疾病包括血小板数量减少或功能异常,如免疫性血小板减少性紫癜(ITP)。治疗ITP的新药物,如血小板生成素受体激动剂(thrombopoietin receptor agonists, TPO-RAs),通过模拟血小板生成素的作用,增加血小板的产生,从而减少出血风险。
  • 骨髓增生异常综合征:骨髓增生异常综合征是一组骨髓细胞异常增生的疾病,可能导致贫血、出血倾向和感染风险增加。目前,治疗这些疾病的新药物研发包括免疫调节剂和靶向治疗药物。例如,免疫抑制剂如环孢素和他克莫司可用于治疗某些类型的骨髓增生异常综合征。

血液和淋巴疾病靶点相关产品推荐

● 靶点蛋白

MS4A1 (CD20)
CSB-MP015007HU
CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL

CSB-MP023974HU1 Activity Verified

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

CSB-MP004900HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP004940HU Activity Verified

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CSB-MP004925HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC50 of human CD33 protein is 4.289- 5.312 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP023983HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml

产品名称 货号 靶点 来源 蛋白标签
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active) CSB-AP005061HU CD19 Mammalian cell C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active) CSB-MP004900HU CD22 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active) CSB-MP004925HU CD33 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-AP005191HU CD40LG E.coli Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-MP004937HU3 CD40LG Mammalian cell N-terminal hFc-Flag-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human T-cell antigen CD7 (CD7), partial (Active) CSB-MP004953HU CD7 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active) CSB-MP004954HU1 CD70 Mammalian cell N-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active) CSB-AP003581HU CSF2 E.coli Tag-Free
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active) CSB-AP003601HU CSF2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active) CSB-AP003651MO Csf2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active) CSB-AP003661MO Csf2 E.coli Tag-Free
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active) CSB-AP003591HU CSF2RA Mammalian cell C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged

● 稳定细胞株

CSB-SC020067HU FACS

CT26/Human ROR1 Stable Cell Line

CSB-SC020067HU

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重组抗体

ALB Recombinant Monoclonal Antibody
CSB-RA264109A0HU
CSB-RA264109A0HU FC

Overlay Peak curve showing HepG2 cells stained with CSB-RA264109A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD3E Recombinant Monoclonal Antibody
CSB-RA004931MA1HU
CSB-RA004931MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.

TOP1 Recombinant Monoclonal Antibody
CSB-RA792129A0HU
CSB-RA792129A0HU FC

Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.

产品名称 货号 靶点 反应种属 应用范围
ALB Recombinant Monoclonal Antibody CSB-RA264109A0HU ALB Human ELISA, FC
C3 Recombinant Monoclonal Antibody CSB-RA303909A0HU C3 Human ELISA, WB, IHC, FC
C3 Recombinant Monoclonal Antibody CSB-RA699863A0HU C3 Human ELISA, IHC
C5 Recombinant Monoclonal Antibody CSB-RA003995MA1HU C5 Human ELISA, FC
CD19 Recombinant Monoclonal Antibody CSB-RA004888A0HU CD19 Human ELISA
CD19 Recombinant Monoclonal Antibody CSB-RA780821A0HU CD19 Human ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody CSB-RA004888MA1HU CD19 Human, Mouse ELISA, WB
CD22 Recombinant Monoclonal Antibody CSB-RA962691A0HU CD22 Human ELISA, IHC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD34 Recombinant Monoclonal Antibody CSB-RA004926A0HU CD34 Human ELISA, IHC
CD38 Recombinant Monoclonal Antibody CSB-RA796695A0HU CD38 Human ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody CSB-RA004931MA1HU CD3E Human ELISA, FC
CD4 Recombinant Monoclonal Antibody CSB-RA004935A0HU CD4 Human ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody CSB-RA004954MA1HU CD70 Human ELISA
CD80 Recombinant Monoclonal Antibody CSB-RA246383A0HU CD80 Human ELISA, WB, IHC, IP
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC

● ELISA试剂盒

产品名称 货号 靶点 检测范围 灵敏度
Bovine Albumin(Alb) ELISA kit CSB-E08664b ALB 0.313 μg/mL-80 μg/mL 0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit CSB-E13878m ALB 0.781 μg/mL-200 μg/mL 0.110 μg/mL
Dog Albumin(Alb) ELISA Kit CSB-E15757c ALB 0.273 μg/mL-35 μg/mL 0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit CSB-E15839Sh ALB 350 μg/mL-21.88 μg/mL 5.5 μg/mL
Horse Albumin(Alb) ELISA Kit CSB-E16205Hs ALB 1.25 μg/mL-80 μg/mL 1.247 μg/mL
Pig Albumin (Alb) ELISA Kit CSB-E16207p ALB 0.03 μg/mL-7000 μg/mL 0.03 μg/mL
Goat Albumin (Alb)ELISA Kit CSB-E15758G ALB 0.17 μg/mL-350 μg/mL 0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit CSB-E15765Gp ALB 0.156 μg/mL-10 μg/mL 0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit CSB-E16204Rb ALB 0.273 μg/mL-70 μg/mL 0.117 μg/mL
Human Complement 3,C3 ELISA Kit CSB-E08665h C3 4.7 ng/mL-300 ng/mL 4.031 ng/mL
Pig Complement 3,C3 ELISA Kit CSB-E06920p C3 0.625 μg/mL-10 μg/mL 0.625 μg/mL
Rat Complement 3,C3 ELISA Kit CSB-E08666r C3 0.625 μg/mL-40 μg/mL 0.156 μg/mL
Mouse Complement 3,C3 ELISA Kit CSB-E08667m C3 93.75 ng/mL-6000 ng/mL 23.44 ng/mL
Rabbit Complement 3,C3 ELISA Kit CSB-E08668Rb C3 27.3 ng/mL-7000 ng/mL 27.3 ng/mL
Fish Complement 3,C3 ELISA Kit CSB-E09727s C3 12.5 μg/mL-500 μg/mL 12.5 μg/mL
Monkey Complement 3(C3)ELISA Kit CSB-E16528Mk C3 4.68 ng/mL-300 ng/mL 1.17 ng/mL
Dog Complement 3(C3)ELISA Kit CSB-EL003888DO C3 0.78 μg/mL-50 μg/mL 0.195 μg/mL
Mouse Complement 5,C5 ELISA Kit CSB-E13802m C5 0.25 ng/mL-16 ng/mL 0.06 ng/mL
Rat Complement fragment 5,C5 ELISA Kit CSB-E14363r C5 9.38 ng/mL-600 ng/mL 2.34 ng/mL
Monkey complement C5 (C5) ELISA kit CSB-EL003995MK C5 0.625 ng/mL-40 ng/mL 0.156 ng/mL