血液和淋巴疾病
非肿瘤性血液和淋巴疾病包括一系列影响血液成分和淋巴系统功能的状况,如贫血、凝血障碍、血小板异常、骨髓增生异常综合征等。这些疾病的治疗方法多样,包括药物治疗、输血、骨髓移植等。近年来,针对这些非肿瘤性血液和淋巴疾病的药物研发也取得了显著进展。
- 贫血:贫血是血液中红细胞数量或血红蛋白含量低于正常水平的疾病。治疗贫血的新药物研发主要集中在刺激红细胞生成的药物,如红细胞生成素(erythropoiesis-stimulating agents, ESAs)。ESAs通过模拟内源性红细胞生成素的作用,促进红细胞的产生,用于治疗慢性肾脏病引起的贫血。
- 凝血障碍:凝血障碍是指血液凝固过程受到影响的疾病,如血友病。在这一领域,新药物的研发主要集中在替代疗法和基因疗法。例如,重组凝血因子的开发为血友病患者提供了有效的替代治疗。此外,基因疗法的研究也在不断进展,旨在通过修复或替换有缺陷的基因来治疗凝血障碍。
- 血小板异常:血小板异常疾病包括血小板数量减少或功能异常,如免疫性血小板减少性紫癜(ITP)。治疗ITP的新药物,如血小板生成素受体激动剂(thrombopoietin receptor agonists, TPO-RAs),通过模拟血小板生成素的作用,增加血小板的产生,从而减少出血风险。
- 骨髓增生异常综合征:骨髓增生异常综合征是一组骨髓细胞异常增生的疾病,可能导致贫血、出血倾向和感染风险增加。目前,治疗这些疾病的新药物研发包括免疫调节剂和靶向治疗药物。例如,免疫抑制剂如环孢素和他克莫司可用于治疗某些类型的骨髓增生异常综合征。
血液和淋巴疾病药物靶点
- ALB
- ASNA
- C3
- C5
- CD19
- CD2
- CD22
- CD247
- CD274
- CD28
- CD33
- CD34
- CD37
- CD38
- CD3E
- CD4
- CD40
- CD40LG
- CD47
- CD52
- CD7
- CD70
- CD79B
- CD80
- CLEC12A
- CSF1R
- CSF2
- CSF2RA
- CSF3R
- CTLA4
- DNA2
- DRD4
- EPOR
- ERBB2
- F10
- F11
- F7
- F8
- F9
- FANCA
- FCGR1A
- FCGR3A
- FCGRT
- FLT3
- GPRC5D
- HAVCR2
- HBB
- HLA-DRA
- ICAM1
- ICOS
- IFNAR1
- Ifngr1
- IGF1R
- IL11RA
- IL12A
- IL12RB1
- IL13
- IL15
- IL15RA
- IL18
- IL1A
- IL1B
- IL1R1
- IL2RA
- IL2RB
- IL3RA
- IL5
- IL6
- IL6R
- IL6ST
- IL7R
- INSR
- KIT
- LAG3
- LILRB4
- MPL
- MS4A1
- NCR1
- NT5E
- PDCD1
- PROC
- PTCRA
- RHD
- ROR1
- SDC1
- SIRPA
- SLAMF7
- TFPI
- TFRC
- TGFB1
- TIGIT
- TK
- TNF
- TNFRSF10B
- TNFRSF13C
- TNFRSF17
- TNFRSF18
- TNFRSF4
- TNFRSF8
- TNFSF11
- TNFSF13
- TNFSF9
- TOP1
- VEGFA
- VWF
血液和淋巴疾病靶点相关产品推荐
● 靶点蛋白
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP023974HU1
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
CSB-MP004900HU
Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP004940HU
Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.
CSB-MP004925HU
Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC50 of human CD33 protein is 4.289- 5.312 ng/ml.
CSB-MP878942HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP023983HU1
Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L (CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml
● 稳定细胞株
CT26/Human ROR1 Stable Cell Line
CSB-SC020067HU
Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重组抗体
CSB-RA264109A0HU
Overlay Peak curve showing HepG2 cells stained with CSB-RA264109A0HU (red line) at 1:50.
CSB-RA878942MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
CSB-RA004931MA1HU
Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.
CSB-RA792129A0HU
Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
ALB Recombinant Monoclonal Antibody | CSB-RA264109A0HU | ALB | Human | ELISA, FC |
C3 Recombinant Monoclonal Antibody | CSB-RA303909A0HU | C3 | Human | ELISA, WB, IHC, FC |
C3 Recombinant Monoclonal Antibody | CSB-RA699863A0HU | C3 | Human | ELISA, IHC |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888A0HU | CD19 | Human | ELISA |
CD19 Recombinant Monoclonal Antibody | CSB-RA780821A0HU | CD19 | Human | ELISA, WB, IHC, IP |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888MA1HU | CD19 | Human, Mouse | ELISA, WB |
CD22 Recombinant Monoclonal Antibody | CSB-RA962691A0HU | CD22 | Human | ELISA, IHC |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD34 Recombinant Monoclonal Antibody | CSB-RA004926A0HU | CD34 | Human | ELISA, IHC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD3E Recombinant Monoclonal Antibody | CSB-RA004931MA1HU | CD3E | Human | ELISA, FC |
CD4 Recombinant Monoclonal Antibody | CSB-RA004935A0HU | CD4 | Human | ELISA, WB, IHC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CD70 Recombinant Monoclonal Antibody | CSB-RA004954MA1HU | CD70 | Human | ELISA |
CD80 Recombinant Monoclonal Antibody | CSB-RA246383A0HU | CD80 | Human | ELISA, WB, IHC, IP |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
● ELISA试剂盒
产品名称 | 货号 | 靶点 | 检测范围 | 灵敏度 |
---|---|---|---|---|
Bovine Albumin(Alb) ELISA kit | CSB-E08664b | ALB | 0.313 μg/mL-80 μg/mL | 0.148 μg/mL |
Mouse Albumin (Alb)ELISA Kit | CSB-E13878m | ALB | 0.781 μg/mL-200 μg/mL | 0.110 μg/mL |
Dog Albumin(Alb) ELISA Kit | CSB-E15757c | ALB | 0.273 μg/mL-35 μg/mL | 0.266 μg/mL |
Sheep Albumin (Alb)ELISA Kit | CSB-E15839Sh | ALB | 350 μg/mL-21.88 μg/mL | 5.5 μg/mL |
Horse Albumin(Alb) ELISA Kit | CSB-E16205Hs | ALB | 1.25 μg/mL-80 μg/mL | 1.247 μg/mL |
Pig Albumin (Alb) ELISA Kit | CSB-E16207p | ALB | 0.03 μg/mL-7000 μg/mL | 0.03 μg/mL |
Goat Albumin (Alb)ELISA Kit | CSB-E15758G | ALB | 0.17 μg/mL-350 μg/mL | 0.17 μg/mL |
Guinea Pig Albumin(Alb) ELISA kit | CSB-E15765Gp | ALB | 0.156 μg/mL-10 μg/mL | 0.09 μg/mL |
Rabbit Albumin(Alb) ELISA Kit | CSB-E16204Rb | ALB | 0.273 μg/mL-70 μg/mL | 0.117 μg/mL |
Human Complement 3,C3 ELISA Kit | CSB-E08665h | C3 | 4.7 ng/mL-300 ng/mL | 4.031 ng/mL |
Pig Complement 3,C3 ELISA Kit | CSB-E06920p | C3 | 0.625 μg/mL-10 μg/mL | 0.625 μg/mL |
Rat Complement 3,C3 ELISA Kit | CSB-E08666r | C3 | 0.625 μg/mL-40 μg/mL | 0.156 μg/mL |
Mouse Complement 3,C3 ELISA Kit | CSB-E08667m | C3 | 93.75 ng/mL-6000 ng/mL | 23.44 ng/mL |
Rabbit Complement 3,C3 ELISA Kit | CSB-E08668Rb | C3 | 27.3 ng/mL-7000 ng/mL | 27.3 ng/mL |
Fish Complement 3,C3 ELISA Kit | CSB-E09727s | C3 | 12.5 μg/mL-500 μg/mL | 12.5 μg/mL |
Monkey Complement 3(C3)ELISA Kit | CSB-E16528Mk | C3 | 4.68 ng/mL-300 ng/mL | 1.17 ng/mL |
Dog Complement 3(C3)ELISA Kit | CSB-EL003888DO | C3 | 0.78 μg/mL-50 μg/mL | 0.195 μg/mL |
Mouse Complement 5,C5 ELISA Kit | CSB-E13802m | C5 | 0.25 ng/mL-16 ng/mL | 0.06 ng/mL |
Rat Complement fragment 5,C5 ELISA Kit | CSB-E14363r | C5 | 9.38 ng/mL-600 ng/mL | 2.34 ng/mL |
Monkey complement C5 (C5) ELISA kit | CSB-EL003995MK | C5 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |