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女性泌尿生殖器疾病和妊娠并发症

女性泌尿生殖器疾病和妊娠并发症是影响女性健康的重要问题。这些疾病包括但不限于尿路感染、阴道炎、子宫内膜异位症、子宫肌瘤、妊娠期糖尿病、妊娠高血压等。

  • 女性泌尿生殖器疾病中,尿路感染和阴道炎较为常见,这些疾病通常由细菌、真菌或病毒引起。治疗这些疾病的药物主要包括抗生素、抗真菌药和抗病毒药。此外,雌激素替代疗法也被用于治疗与绝经相关的泌尿生殖系统症状。
  • 妊娠并发症包括妊娠期糖尿病、妊娠高血压、子痫前期等,这些疾病对孕妇和胎儿的健康构成重大风险。治疗妊娠并发症的药物研发主要集中在控制血糖、血压和改善胎儿生长等方面。

女性泌尿生殖器疾病和妊娠并发症相关信号通路

Hippo signaling pathway

Hippo signaling pathway

Hippo信号通路在细胞增殖、分化、迁移和凋亡中起关键作用。研究表明,miR21通过干扰PP2A Bb调节Hippo信号通路,进而抑制滋养层细胞侵袭,与子痫前期(PE)的发病机制有关 [1]

Jak-STAT signaling pathway

Jak-STAT signaling pathway

异常的STAT信号传导与妊娠疾病的发生有关,包括反复着床失败、先兆子痫、反复自然流产、早产和妊娠期糖尿病等 [2]

Notch signaling pathway

Notch signaling pathway

Notch信号通路影响滋养细胞的分化、增殖、浸润及迁移,参与胚胎着床、胎盘及其血管形成,与妊娠相关疾病的发生与发展有关 [3]

女性泌尿生殖器疾病和妊娠并发症靶点相关产品推荐

● 靶点蛋白

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

ERBB2 (HER2)
CSB-MP007763HU
CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP009411HU Activity Verified

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

CSB-MP011649HU3 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL2RA at 2μg/mL can bind Anti-IL2RA recombinant antibody (CSB-RA011649MA1HU),the EC50 is 2.463-3.353 ng/mL.

CSB-MP006163HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP015044HUc9 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized MSLN at 2 μg/ml can bind Anti-MSLN rabbit monoclonal antibody, the EC50 of the MSLN protein is 2.657-3.177 ng/ml.

产品名称 货号 靶点 来源 蛋白标签
Recombinant Human Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707HU(A4) ANGPT2 Mammalian cell C-terminal 10xHis-tagged
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707DO ANGPT2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active) CSB-AP005061HU CD19 Mammalian cell C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active) CSB-MP004900HU CD22 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active) CSB-MP733578HU CD276 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-AP005191HU CD40LG E.coli Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-MP004937HU3 CD40LG Mammalian cell N-terminal hFc-Flag-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active) CSB-MP004954HU1 CD70 Mammalian cell N-terminal 10xHis-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) CSB-MP005165HU CEACAM5 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Claudin-6 (CLDN6)-VLPs (Active) CSB-MP005508HU(A4) CLDN6 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active) CSB-MP005508HU(A4)f4 CLDN6 Mammalian cell C-terminal GFP-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active) CSB-AP003591HU CSF2RA Mammalian cell C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged

● 稳定细胞株

CSB-SC005508HU FACS

HEK293T/Human CLDN6 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human CLDN6 HEK293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-SC007681HU FACS

HEK293T/Human ENPP3 Stable Cell Line

CSB-SC007681HU

Untransfected HEK293T cells (green line) and transfected Human ENPP3 HEK293T Stable cells (red line) were stained with anti-ENPP3 antibody (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重组抗体

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU
CSB-RA244537A0HU FC

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

产品名称 货号 靶点 反应种属 应用范围
ALB Recombinant Monoclonal Antibody CSB-RA264109A0HU ALB Human ELISA, FC
ANGPT2 Recombinant Monoclonal Antibody CSB-RA191985A0HU ANGPT2 Human ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody CSB-RA001707MA01HU ANGPT2 Human ELISA
C5 Recombinant Monoclonal Antibody CSB-RA003995MA1HU C5 Human ELISA, FC
CA9 Recombinant Monoclonal Antibody CSB-RA614990A0HU CA9 Human ELISA, IHC
CD19 Recombinant Monoclonal Antibody CSB-RA004888A0HU CD19 Human ELISA
CD19 Recombinant Monoclonal Antibody CSB-RA780821A0HU CD19 Human ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody CSB-RA004888MA1HU CD19 Human, Mouse ELISA, WB
CD22 Recombinant Monoclonal Antibody CSB-RA962691A0HU CD22 Human ELISA, IHC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody CSB-RA796695A0HU CD38 Human ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody CSB-RA004954MA1HU CD70 Human ELISA
CD80 Recombinant Monoclonal Antibody CSB-RA246383A0HU CD80 Human ELISA, WB, IHC, IP
CDH6 Recombinant Monoclonal Antibody CSB-RA005055MA1HU CDH6 Human ELISA
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA3HU CEACAM5 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA1HU CEACAM5 Human ELISA

● ELISA试剂盒

产品名称 货号 靶点 检测范围 灵敏度
Bovine Albumin(Alb) ELISA kit CSB-E08664b ALB 0.313 μg/mL-80 μg/mL 0.148 μg/mL
Mouse Albumin (Alb)ELISA Kit CSB-E13878m ALB 0.781 μg/mL-200 μg/mL 0.110 μg/mL
Dog Albumin(Alb) ELISA Kit CSB-E15757c ALB 0.273 μg/mL-35 μg/mL 0.266 μg/mL
Sheep Albumin (Alb)ELISA Kit CSB-E15839Sh ALB 350 μg/mL-21.88 μg/mL 5.5 μg/mL
Horse Albumin(Alb) ELISA Kit CSB-E16205Hs ALB 1.25 μg/mL-80 μg/mL 1.247 μg/mL
Pig Albumin (Alb) ELISA Kit CSB-E16207p ALB 0.03 μg/mL-7000 μg/mL 0.03 μg/mL
Goat Albumin (Alb)ELISA Kit CSB-E15758G ALB 0.17 μg/mL-350 μg/mL 0.17 μg/mL
Guinea Pig Albumin(Alb) ELISA kit CSB-E15765Gp ALB 0.156 μg/mL-10 μg/mL 0.09 μg/mL
Rabbit Albumin(Alb) ELISA Kit CSB-E16204Rb ALB 0.273 μg/mL-70 μg/mL 0.117 μg/mL
Human Angiopoietin 2,ANG-2 ELISA Kit CSB-E04500h ANGPT2 39 pg/mL-2500 pg/mL 9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit CSB-E07304r ANGPT2 Request Information Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit CSB-E07305m ANGPT2 0.156 pg/mL-10 pg/mL 0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit CSB-E08460p ANGPT2 0.94 ng/mL-60 ng/mL 0.235 ng/mL
Human Tyrosine-protein kinase receptor UFO (AXL) ELISA Kit CSB-EL002476HU AXL 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Mouse Tyrosine-protein kinase receptor UFO(AXL) ELISA Kit CSB-EL002476MO AXL 31.25 pg/ml-2000 pg/ml 7.81 pg/ml
Mouse Complement 5,C5 ELISA Kit CSB-E13802m C5 0.25 ng/mL-16 ng/mL 0.06 ng/mL
Rat Complement fragment 5,C5 ELISA Kit CSB-E14363r C5 9.38 ng/mL-600 ng/mL 2.34 ng/mL
Monkey complement C5 (C5) ELISA kit CSB-EL003995MK C5 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human Carbonic Anhydrase 9(CA9) ELISA Kit CSB-E13266h CA9 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL

参考文献:

[1] MiR21 modulates the Hippo signaling pathway via interference with PP2A Bb to inhibit trophoblast invasion and cause preeclampsia [J].Molecular Therapy: Nucleic Acids, 2022.

[2] Research progress on the STAT signaling pathway in pregnancy and pregnancy-associated disorders [J].Front Immunol,2023.

[3] Notch signalling in placental development and gestational diseases [J].Placenta,2017.

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