脑癌
脑癌是指发生在脑部的恶性肿瘤,包括原发性脑癌和继发性脑癌。原发性脑癌起源于脑组织或邻近组织,如脑膜,而继发性脑癌则是由其他部位的癌症转移至脑部形成的。脑癌的症状多样,包括头痛、恶心、呕吐、视力障碍、癫痫发作等,这些症状与肿瘤的大小、位置和生长速度有关。
在脑癌的治疗方面,传统的治疗手段包括手术切除、放疗和化疗。然而,由于血脑屏障的存在,许多药物难以有效到达脑部肿瘤部位,限制了治疗效果。近年来,针对脑癌的药物研究主要集中在靶向治疗和免疫治疗领域。
- 靶向治疗:靶向治疗药物通过特异性作用于肿瘤细胞的特定分子靶点,从而抑制肿瘤的生长和扩散。例如,MET抑制剂卡马替尼(Capmatinib)和特泊替尼(Tepotinib)已获批上市,用于治疗MET14外显子跳跃突变的转移性非小细胞肺癌,而MET抑制剂在脑癌领域的研究也在进行中。
- 免疫治疗:免疫治疗通过激活或增强患者自身的免疫系统来攻击肿瘤细胞。PD-1/L1抗体药物如Nivolumab和Pembrolizumab已在一些脑癌治疗中显示出潜力,尽管目前针对GBM的III期临床试验未获成功,但免疫治疗仍然是研究的热点。
- 细胞免疫疗法:包括CAR-T细胞疗法和CIK细胞疗法等,通过改造患者的免疫细胞使其能够识别和攻击肿瘤细胞。例如,靶向EGFRvIII的CAR-T产品正在开发中,用于治疗GBM1。
- 溶瘤病毒疗法:利用改造后的病毒特异性感染和杀死肿瘤细胞。例如,基于HSV-1改造的溶瘤病毒G207在治疗儿童和青少年高级别胶质瘤的临床试验中显示出生存期延长的效果。
脑癌药物靶点
脑癌药物靶点相关产品推荐
● 靶点蛋白
CSB-MP007479HU
Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
CSB-MP733578HU
Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC50 of human CD276 protein is 1.961-2.243 ng/ml.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP007763HU
Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.
CSB-MP878942HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP023997HU1
Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9(CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL
CSB-MP001707HU(A4)
Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL
FACS assay shows that Human PVR can bind to HEK293F cell overexpressing human TIGIT.
● 重组抗体
CSB-RA878942MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
CSB-RA004931MA1HU
Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.
CSB-RA159341A0HU
Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.
CSB-RA919940A0HU
Overlay Peak curve showing 3T3 cells stained with CSB-RA919940A0HU (red line) at 1:50.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA191985A0HU | ANGPT2 | Human | ELISA, IHC |
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA001707MA01HU | ANGPT2 | Human | ELISA |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD3E Recombinant Monoclonal Antibody | CSB-RA004931MA1HU | CD3E | Human | ELISA, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA3HU | CEACAM5 | Human | ELISA, IF, FC |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA1HU | CEACAM5 | Human | ELISA |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA260392A0HU | ERBB2 | Human | ELISA, IHC, IF |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA1HU | ERBB2 | Human | ELISA |
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody | CSB-RA588766A0HU | ERBB2 | Human | ELISA, IHC, IF |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA2HU | ERBB2 | Human | ELISA, IHC |
ERBB3 Recombinant Monoclonal Antibody | CSB-RA937008A0HU | ERBB3 | Human | ELISA, IF |
FN1 Recombinant Monoclonal Antibody | CSB-RA921689A0HU | FN1 | Human | ELISA, IHC |
● ELISA试剂盒
产品名称 | 货号 | 靶点 | 检测范围 | 灵敏度 |
---|---|---|---|---|
Bovine Angiopoietin-1(ANGPT1) ELISA kit | CSB-EL001706BO | ANGPT1 | 12.5 ng/mL-800 ng/mL | 1.384 ng/mL |
Human Angiopoietin-1(ANGPT1) ELISA kit | CSB-EL001706HU | ANGPT1 | 1.25 ng/mL-80 ng/mL | 0.091 ng/mL |
Mouse Angiopoietin 1,ANG-1 ELISA Kit | CSB-E07302m | ANGPT1 | 1.25 ng/mL-80 ng/mL | 0.312 ng/mL |
Rat Angiopoietin 1,ANG-1 ELISA Kit | CSB-E07303r | ANGPT1 | 6.25 ng/mL-400 ng/mL | 1.56 ng/mL |
Pig Angiopoietin 1,ANG-1 ELISA Kit | CSB-E08457p | ANGPT1 | 6 ng/mL-200 ng/mL | 6 ng/mL |
Human Angiopoietin 2,ANG-2 ELISA Kit | CSB-E04500h | ANGPT2 | 39 pg/mL-2500 pg/mL | 9.75 pg/mL |
Rat Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07304r | ANGPT2 | Request Information | Request Information |
Mouse Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07305m | ANGPT2 | 0.156 pg/mL-10 pg/mL | 0.039 pg/mL |
Pig Angiopoietin 2,ANG-2 ELISA Kit | CSB-E08460p | ANGPT2 | 0.94 ng/mL-60 ng/mL | 0.235 ng/mL |
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | CSB-E13644h | CD274 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | CSB-EL004911MO | CD274 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit | CSB-E14285h | CD276 | 3.12 ng/mL-200 ng/mL | 0.78 ng/mL |
Human Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940HU | CD47 | 3.12 pg/mL-200 pg/mL | 0.78 pg/mL |
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940MO | CD47 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Human carcinoembryonic antigen,CEA ELISA Kit | CSB-E04767h | CEACAM5 | 5 ng/mL-120 ng/mL | 2 ng/mL |
Mouse carcinoembryonic antign,CEA ELISA Kit | CSB-E13925m | CEACAM5 | 62.5 pg/mL-4000 pg/mL | 15.6 pg/mL |
Human epidermal growth factor receptor,EGFR ELISA Kit | CSB-E12124h | EGFR | 0.312 ng/mL-20 ng/mL | 0.019 ng/mL |
Mouse Soluble Endoglin,ENG/sCD105 ELISA Kit | CSB-E09921m | ENG | 6.25 ng/mL-400 ng/mL | 1.56 ng/mL |
Human Soluble Endoglin,sENG/sCD105 ELISA Kit | CSB-E10030h | ENG | 0.156 ng/mL-10 ng/mL | 0.047 ng/mL |