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脑癌

脑癌是指发生在脑部的恶性肿瘤,包括原发性脑癌和继发性脑癌。原发性脑癌起源于脑组织或邻近组织,如脑膜,而继发性脑癌则是由其他部位的癌症转移至脑部形成的。脑癌的症状多样,包括头痛、恶心、呕吐、视力障碍、癫痫发作等,这些症状与肿瘤的大小、位置和生长速度有关。

在脑癌的治疗方面,传统的治疗手段包括手术切除、放疗和化疗。然而,由于血脑屏障的存在,许多药物难以有效到达脑部肿瘤部位,限制了治疗效果。近年来,针对脑癌的药物研究主要集中在靶向治疗和免疫治疗领域。

  • 靶向治疗:靶向治疗药物通过特异性作用于肿瘤细胞的特定分子靶点,从而抑制肿瘤的生长和扩散。例如,MET抑制剂卡马替尼(Capmatinib)和特泊替尼(Tepotinib)已获批上市,用于治疗MET14外显子跳跃突变的转移性非小细胞肺癌,而MET抑制剂在脑癌领域的研究也在进行中。
  • 免疫治疗:免疫治疗通过激活或增强患者自身的免疫系统来攻击肿瘤细胞。PD-1/L1抗体药物如Nivolumab和Pembrolizumab已在一些脑癌治疗中显示出潜力,尽管目前针对GBM的III期临床试验未获成功,但免疫治疗仍然是研究的热点。
  • 细胞免疫疗法:包括CAR-T细胞疗法和CIK细胞疗法等,通过改造患者的免疫细胞使其能够识别和攻击肿瘤细胞。例如,靶向EGFRvIII的CAR-T产品正在开发中,用于治疗GBM1。
  • 溶瘤病毒疗法:利用改造后的病毒特异性感染和杀死肿瘤细胞。例如,基于HSV-1改造的溶瘤病毒G207在治疗儿童和青少年高级别胶质瘤的临床试验中显示出生存期延长的效果。

脑癌药物靶点相关产品推荐

● 靶点蛋白

CSB-MP007479HU Activity Verified

Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.

CSB-MP733578HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD276 at 2 μg/ml can bind Anti-CD276 rabbit monoclonal antibody, the EC50 of human CD276 protein is 1.961-2.243 ng/ml.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP007763HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody(CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP023997HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9(CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL

CSB-MP001707HU(A4) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL

CSB-MP019093HU(M) Activity Verified

FACS assay shows that Human PVR can bind to HEK293F cell overexpressing human TIGIT.

产品名称 货号 靶点 来源 蛋白标签
Recombinant Human Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707HU(A4) ANGPT2 Mammalian cell C-terminal 10xHis-tagged
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707DO ANGPT2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD276 antigen (CD276), partial (Active) CSB-MP733578HU CD276 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) (E398K) (Active) CSB-MP005165HU CEACAM5 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active) CSB-AP003591HU CSF2RA Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-3 (ERBB3), partial (Active) CSB-MP007765HU ERBB3 Mammalian cell C-terminal hFc-tagged
Recombinant Human Fibronectin (FN1), partial (Active) CSB-AP005751HU FN1 E.coli Tag-Free
Recombinant Human Interleukin-2 receptor subunit alpha (IL2RA), partial (Active) CSB-MP011649HU3 IL2RA Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial (Active) CSB-AP004271HU IL4R Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial (Active) CSB-AP004281HU IL4R Mammalian cell C-terminal Fc-tagged
Recombinant Human Interleukin-4 receptor subunit alpha (IL4R), partial,Biotinylated (Active) CSB-MP011661HU2-B IL4R Mammalian cell C-terminal 10xHis-Avi-tagged
Recombinant Human B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) CSB-MP015007HU MS4A1 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Dog B-lymphocyte antigen CD20 (MS4A1)-VLPs (Active) CSB-MP661636DO MS4A1 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Macaca fascicularis Membrane spanning 4-domains A1 (MS4A1)-VLPs (Active) CSB-MP4516MOV MS4A1 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Programmed cell death protein 1 (PDCD1), partial (Active) CSB-MP619964HU1 PDCD1 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Poliovirus receptor (PVR) (I340M), partial (Active) CSB-MP019093HU(M) PVR Mammalian cell C-terminal hFc-tagged
Recombinant Human Transforming growth factor beta-1 proprotein (TGFB1), partial (Active) CSB-AP003861HU TGFB1 Mammalian cell Tag-Free
Recombinant Mouse Transforming growth factor beta-1 proprotein (Tgfb1), partial (Active) CSB-AP004111MO Tgfb1 Mammalian cell Tag-Free
Recombinant Human Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), partial (Active) CSB-MP023977HU1 TNFRSF1A Mammalian cell C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor ligand superfamily member 9 protein (TNFSF9), partial (Active) CSB-AP001961HU TNFSF9 E.Coli Tag-Free
Recombinant Human Tumor necrosis factor ligand superfamily member 9 (TNFSF9), partial (Active) CSB-MP023997HU1 TNFSF9 Mammalian cell N-terminal hFc-Myc-tagged

● 重组抗体

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

CD3E Recombinant Monoclonal Antibody
CSB-RA004931MA1HU
CSB-RA004931MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

FN1 Recombinant Monoclonal Antibody
CSB-RA919940A0HU
CSB-RA919940A0HU FC

Overlay Peak curve showing 3T3 cells stained with CSB-RA919940A0HU (red line) at 1:50.

产品名称 货号 靶点 反应种属 应用范围
ANGPT2 Recombinant Monoclonal Antibody CSB-RA191985A0HU ANGPT2 Human ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody CSB-RA001707MA01HU ANGPT2 Human ELISA
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD3E Recombinant Monoclonal Antibody CSB-RA004931MA1HU CD3E Human ELISA, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA3HU CEACAM5 Human ELISA, IF, FC
CEACAM5 Recombinant Monoclonal Antibody CSB-RA005165MA1HU CEACAM5 Human ELISA
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody CSB-RA260392A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU ERBB2 Human ELISA
Phospho-ERBB2 (Y1139) Recombinant Monoclonal Antibody CSB-RA588766A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA2HU ERBB2 Human ELISA, IHC
ERBB3 Recombinant Monoclonal Antibody CSB-RA937008A0HU ERBB3 Human ELISA, IF
FN1 Recombinant Monoclonal Antibody CSB-RA921689A0HU FN1 Human ELISA, IHC

● ELISA试剂盒

产品名称 货号 靶点 检测范围 灵敏度
Bovine Angiopoietin-1(ANGPT1) ELISA kit CSB-EL001706BO ANGPT1 12.5 ng/mL-800 ng/mL 1.384 ng/mL
Human Angiopoietin-1(ANGPT1) ELISA kit CSB-EL001706HU ANGPT1 1.25 ng/mL-80 ng/mL 0.091 ng/mL
Mouse Angiopoietin 1,ANG-1 ELISA Kit CSB-E07302m ANGPT1 1.25 ng/mL-80 ng/mL 0.312 ng/mL
Rat Angiopoietin 1,ANG-1 ELISA Kit CSB-E07303r ANGPT1 6.25 ng/mL-400 ng/mL 1.56 ng/mL
Pig Angiopoietin 1,ANG-1 ELISA Kit CSB-E08457p ANGPT1 6 ng/mL-200 ng/mL 6 ng/mL
Human Angiopoietin 2,ANG-2 ELISA Kit CSB-E04500h ANGPT2 39 pg/mL-2500 pg/mL 9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit CSB-E07304r ANGPT2 Request Information Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit CSB-E07305m ANGPT2 0.156 pg/mL-10 pg/mL 0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit CSB-E08460p ANGPT2 0.94 ng/mL-60 ng/mL 0.235 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Soluble CD276,sCD276/sB7-H3 ELISA Kit CSB-E14285h CD276 3.12 ng/mL-200 ng/mL 0.78 ng/mL
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human carcinoembryonic antigen,CEA ELISA Kit CSB-E04767h CEACAM5 5 ng/mL-120 ng/mL 2 ng/mL
Mouse carcinoembryonic antign,CEA ELISA Kit CSB-E13925m CEACAM5 62.5 pg/mL-4000 pg/mL 15.6 pg/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Mouse Soluble Endoglin,ENG/sCD105 ELISA Kit CSB-E09921m ENG 6.25 ng/mL-400 ng/mL 1.56 ng/mL
Human Soluble Endoglin,sENG/sCD105 ELISA Kit CSB-E10030h ENG 0.156 ng/mL-10 ng/mL 0.047 ng/mL