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营养代谢病

营养代谢病是一组由营养代谢异常引起的疾病,包括但不限于糖尿病、肥胖、心血管疾病、脂肪肝等。营养代谢病通常与体内营养物质的代谢失衡有关,可能是由于酶的缺陷、激素水平异常、遗传因素或生活方式等多种因素引起的。

营养代谢病的药物研发聚焦于多个关键靶点,以下是一些重要的靶点及其研发进展:

  • GLP-1R/GIPR:受体和GIP受体是治疗肥胖和糖尿病的重要靶点。基于这些靶点的药物能够改善胰岛素分泌和降低血糖水平。例如,Amgen的AMG 133(Anti-GIPR单抗融合GLP-1)在治疗肥胖的Ⅰ期临床数据中表现出显著的减重效果。
  • INHBE:INHBE(Inhibin beta E chain)是TGF-β超家族的成员,主要在肝脏表达,与体脂分布和代谢健康相关。研究发现INHBE基因的功能丧失突变与较低的腰臀比和良好的代谢特征相关,表明INHBE是潜在的治疗靶点。
  • lysosomal AMPK(PEN2/Aldolase):AMPK是代谢稳态的关键控制器。通过特定抑制PEN2或Aldolase,可以模拟细胞葡萄糖饥饿,激活溶酶体AMPK,从而降低脂肪肝、缓解高血糖,为代谢疾病治疗提供了新思路。
  • CIDEB:CIDEB基因与肝脏脂质代谢相关,Alnylam公司与再生元合作开发靶向CIDEB的RNAi疗法,预计进入临床开发阶段,为NASH治疗提供了新的靶点。
  • SLC转运蛋白家族:SLC转运蛋白在多种代谢性疾病中起重要作用,包括二型糖尿病、高血压等。SLC转运蛋白作为药物靶点的研究显示它们可以转运营养素、代谢物以及药物分子,是慢性病重要的药物靶点。
  • PCSK9:PCSK9(原蛋白转化酶枯草杆菌酶 9 型)是降低胆固醇治疗的热门靶点。基于RNA干扰技术的PCSK9抑制剂,如inclisiran,已获得批准用于治疗高胆固醇血症。
  • GDF15:生长分化因子15(GDF15)是一种调节能量代谢的信号分子,其分泌受肝脏Glce的调控,影响机体肝脂代谢的稳态平衡,可能成为对抗肥胖的潜在靶点1。
  • SLC13A5:SLC13A5作为一个具有极大开发潜力的靶点,研究其在代谢性疾病中的作用机制以及药物设计与开发具有重要意义。

营养代谢病靶点相关产品推荐

● 靶点蛋白

CSB-MP023974HU1 Activity Verified

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

CSB-MP009411HU Activity Verified

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

MS4A1 (CD20)
CSB-MP015007HU
CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL

CSB-MP004940HU Activity Verified

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CSB-MP882153HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D at 5 μg/mL can bind Anti-GPRC5D recombinant antibody (CSB-RA882153MA01HU), the EC50 is 8.847-10.38 ng/mL.

CSB-YP011664HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU),the EC50 is 35.80-41.82 ng/mL.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP001707HU(A4) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL

产品名称 货号 靶点 来源 蛋白标签
Recombinant Human ATP-binding cassette sub-family D member 1 (ABCD1) (Active) CSB-CF001068HU ABCD1 in vitro E.coli expression system C-terminal 10xHis-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-AP005191HU CD40LG E.coli Tag-Free
Recombinant Human CD40 ligand (CD40LG), partial (Active) CSB-MP004937HU3 CD40LG Mammalian cell N-terminal hFc-Flag-tagged
Recombinant Human T-lymphocyte activation antigen CD86 (CD86), partial (Active) CSB-AP005161HU CD86 Mammalian cell C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged
Recombinant Human Glucagon receptor (GCGR), partial (Active) CSB-MP009316HU1 GCGR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Growth hormone receptor (GHR), partial (Active) CSB-MP009411HU GHR Mammalian cell C-terminal hFc-tagged
Recombinant Human Growth hormone receptor (GHR), partial, Biotinylated (Active) CSB-MP009411HUj1-B GHR Mammalian cell C-terminal mFc-Avi-tagged
Recombinant Mouse Gastric inhibitory polypeptide receptor (Gipr), partial (Active) CSB-MP009438MO1 Gipr Mammalian cell C-terminal 10xHis-tagged
Recombinant Rat Gastric inhibitory polypeptide receptor (Gipr), partial (Active) CSB-MP009438RA1 Gipr Mammalian cell C-terminal 10xHis-tagged
Recombinant Macaca Gastric inhibitory polypeptide receptor (GIPR), partial (Active) CSB-YP4825MOV GIPR Yeast N-terminal 6xHis-tagged
Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) CSB-MP009514HUb1 GLP1R Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Interleukin-15 protein (IL15) (Active) CSB-AP001621HU IL15 E.Coli Tag-Free
Recombinant Human Interleukin-15 (IL15) (Active) CSB-AP004391HU IL15 E.coli Tag-Free
Recombinant Human Interleukin-17A (IL17A) (Active) CSB-AP004331HU IL17A E.coli Tag-Free

● 重组抗体

C5 Recombinant Monoclonal Antibody
CSB-RA003995MA1HU
CSB-RA003995MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA003995MA1HU (red line) at 1:800.

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU
CSB-RA244537A0HU FC

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CD40 Recombinant Monoclonal Antibody
CSB-RA004936MA1HU
CSB-RA004936MA1HU FC

Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.

CTLA4 Recombinant Monoclonal Antibody
CSB-RA006163MA1HU
CSB-RA006163MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.

产品名称 货号 靶点 反应种属 应用范围
APP Recombinant Monoclonal Antibody CSB-RA994273A0HU APP Human, Mouse, Rat ELISA, WB, IF
C5 Recombinant Monoclonal Antibody CSB-RA003995MA1HU C5 Human ELISA, FC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD38 Recombinant Monoclonal Antibody CSB-RA796695A0HU CD38 Human ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD80 Recombinant Monoclonal Antibody CSB-RA246383A0HU CD80 Human ELISA, WB, IHC, IP
CD86 Recombinant Monoclonal Antibody CSB-RA004965A0HU CD86 Human ELISA, WB
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
FGFR1 Recombinant Monoclonal Antibody CSB-RA008642MA1HU FGFR1 Human ELISA, IHC, IF, FC
GAA Recombinant Monoclonal Antibody CSB-RA566370A0HU GAA Human ELISA, IHC
GCGR Recombinant Monoclonal Antibody CSB-RA009316A1HU GCGR Human ELISA
GDF15 Recombinant Monoclonal Antibody CSB-RA285852A0HU GDF15 Human ELISA, IHC
GHR Recombinant Monoclonal Antibody CSB-RA978909A0HU GHR Human ELISA, IHC, IF
Gipr Recombinant Monoclonal Antibody CSB-RA009438MA1MO Gipr Mouse、Rat ELISA
GIPR Recombinant Monoclonal Antibody CSB-RA009438MA2HU GIPR Human ELISA, WB
GIPR Recombinant Monoclonal Antibody CSB-RA009438MA1HU GIPR Human, Macaca fascicularis ELISA
GLP1R Recombinant Monoclonal Antibody CSB-RA009514MA1HU GLP1R Human ELISA
IGF1R Recombinant Monoclonal Antibody CSB-RA011087MA1HU IGF1R Human ELISA, FC
IL17A Recombinant Monoclonal Antibody CSB-RA624104MA1HU IL17A Human ELISA

● ELISA试剂盒

产品名称 货号 靶点 检测范围 灵敏度
Human angiopoietin-like protein 3,ANGPTL3 ELISA Kit CSB-E11724h ANGPTL3 78 pg/mL-5000 pg/mL 19.5 pg/mL
Mouse Angiopoietin-related protein 3(ANGPTL3) ELISA kit CSB-EL001711MO ANGPTL3 31.25 pg/mL-2000 pg/mL 10.24 pg/mL
Human apolipoprotein A1 (Apo-A1) ELISA Kit CSB-E08103h APOA1 1.4 ng/mL-1000 ng/mL 0.7 ng/mL
Rat apolipoprotein A1 (Apo-A1) ELISA Kit CSB-E08105r APOA1 0.14 ng/ml-100 ng/ml. 0.14 ng/ml.
Pig apolipoprotein A1 (Apo-A1) ELISA Kit CSB-E06834p APOA1 80 μg/mL-2000 μg/mL 50 μg/mL
Mouse apolipoprotein A1(Apo-A1) ELISA Kit CSB-E08104m APOA1 31.25 ng/mL-2000 ng/mL 7.81 ng/mL
Rabbit apolipoprotein A1 (Apo-A1) ELISA Kit CSB-E09804Rb APOA1 6.25 μg/mL-400 μg/mL 1.56 μg/mL
Bovine Apolipoprotein A-I(APOA1) ELISA kit CSB-EL001913BO APOA1 78 ng/mL-5000 ng/mL 19.5 ng/mL
Dog Apolipoprotein A-I(APOA1) ELISA kit CSB-EL001913DO APOA1 28.12 ng/mL-1800 ng/mL 7 ng/mL
Rat Amyloid beta A4 protein(APP) ELISA kit CSB-EL001950RA APP 15.6 ng/mL-1000 ng/mL 3.9 ng/mL
Mouse Complement 5,C5 ELISA Kit CSB-E13802m C5 0.25 ng/mL-16 ng/mL 0.06 ng/mL
Rat Complement fragment 5,C5 ELISA Kit CSB-E14363r C5 9.38 ng/mL-600 ng/mL 2.34 ng/mL
Monkey complement C5 (C5) ELISA kit CSB-EL003995MK C5 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human Uncharacterized protein C9orf72(C9orf72) ELISA kit CSB-EL004345HU C9orf72 31.25 pg/mL-2000 pg/mL 7.8 pg/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human soluble cluster of differentiation 28,sCD28 ELISA Kit CSB-E09296h CD28 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit CSB-E09884h CD38 0.9 ng/mL-60 ng/mL 0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit CSB-EL004929MO CD38 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit CSB-E04716h CD40LG 0.312 ng/mL-20 ng/mL 0.078 ng/mL