营养代谢病
营养代谢病是一组由营养代谢异常引起的疾病,包括但不限于糖尿病、肥胖、心血管疾病、脂肪肝等。营养代谢病通常与体内营养物质的代谢失衡有关,可能是由于酶的缺陷、激素水平异常、遗传因素或生活方式等多种因素引起的。
营养代谢病的药物研发聚焦于多个关键靶点,以下是一些重要的靶点及其研发进展:
- GLP-1R/GIPR:受体和GIP受体是治疗肥胖和糖尿病的重要靶点。基于这些靶点的药物能够改善胰岛素分泌和降低血糖水平。例如,Amgen的AMG 133(Anti-GIPR单抗融合GLP-1)在治疗肥胖的Ⅰ期临床数据中表现出显著的减重效果。
- INHBE:INHBE(Inhibin beta E chain)是TGF-β超家族的成员,主要在肝脏表达,与体脂分布和代谢健康相关。研究发现INHBE基因的功能丧失突变与较低的腰臀比和良好的代谢特征相关,表明INHBE是潜在的治疗靶点。
- lysosomal AMPK(PEN2/Aldolase):AMPK是代谢稳态的关键控制器。通过特定抑制PEN2或Aldolase,可以模拟细胞葡萄糖饥饿,激活溶酶体AMPK,从而降低脂肪肝、缓解高血糖,为代谢疾病治疗提供了新思路。
- CIDEB:CIDEB基因与肝脏脂质代谢相关,Alnylam公司与再生元合作开发靶向CIDEB的RNAi疗法,预计进入临床开发阶段,为NASH治疗提供了新的靶点。
- SLC转运蛋白家族:SLC转运蛋白在多种代谢性疾病中起重要作用,包括二型糖尿病、高血压等。SLC转运蛋白作为药物靶点的研究显示它们可以转运营养素、代谢物以及药物分子,是慢性病重要的药物靶点。
- PCSK9:PCSK9(原蛋白转化酶枯草杆菌酶 9 型)是降低胆固醇治疗的热门靶点。基于RNA干扰技术的PCSK9抑制剂,如inclisiran,已获得批准用于治疗高胆固醇血症。
- GDF15:生长分化因子15(GDF15)是一种调节能量代谢的信号分子,其分泌受肝脏Glce的调控,影响机体肝脂代谢的稳态平衡,可能成为对抗肥胖的潜在靶点1。
- SLC13A5:SLC13A5作为一个具有极大开发潜力的靶点,研究其在代谢性疾病中的作用机制以及药物设计与开发具有重要意义。
营养代谢病药物靶点
- ABCD1
- ALPL
- AMY3
- ANGPTL3
- APOA1
- APP
- ARSA
- C5
- C9orf72
- CASR
- CD2
- CD247
- CD28
- CD38
- CD40
- CD40LG
- CD80
- CD86
- CNTFR
- CSF3R
- CTLA4
- EpoR
- FANCA
- FGF21
- FGF23
- FGFR1
- FXN
- GAA
- GALC
- GBA1
- GCGR
- GDF15
- GHR
- GIPR
- GK
- GLP1R
- GLP2R
- GRN
- HEXA
- HEXB
- IAPP
- IDS
- IDUA
- Ifngr1
- IGF1R
- IGF2R
- IL10RA
- IL15
- IL17A
- IL1A
- IL1B
- IL1R1
- IL2RA
- IL2RG
- IL6
- INSR
- KLB
- LEPR
- LPL
- MADCAM1
- MT-ND4
- NPY2R
- OTC
- PAH
- PCSK9
- PDCD1
- PGF
- PTHLH
- SGSH
- SIRT6
- SLC25A21
- SORT1
- SOST
- TARDBP
- TFRC
- TGFB1
- TMPRSS6
- TNF
- TNFRSF17
- TNFSF11
- TTR
- TYRO3
- UGT1A1
- VEGFA
营养代谢病靶点相关产品推荐
● 靶点蛋白
CSB-MP023974HU1
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP004940HU
Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.
CSB-MP882153HU
Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D at 5 μg/mL can bind Anti-GPRC5D recombinant antibody (CSB-RA882153MA01HU), the EC50 is 8.847-10.38 ng/mL.
Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU),the EC50 is 35.80-41.82 ng/mL.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP001707HU(A4)
Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL
● 重组抗体
CSB-RA003995MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA003995MA1HU (red line) at 1:800.
CSB-RA244537A0HU
Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.
CSB-RA004936MA1HU
Overlay Peak curve showing THP-1 cells surface stained with CSB-RA004936MA1HU (red line) at 1:100.
CSB-RA006163MA1HU
Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
APP Recombinant Monoclonal Antibody | CSB-RA994273A0HU | APP | Human, Mouse, Rat | ELISA, WB, IF |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD80 Recombinant Monoclonal Antibody | CSB-RA246383A0HU | CD80 | Human | ELISA, WB, IHC, IP |
CD86 Recombinant Monoclonal Antibody | CSB-RA004965A0HU | CD86 | Human | ELISA, WB |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
FGFR1 Recombinant Monoclonal Antibody | CSB-RA008642MA1HU | FGFR1 | Human | ELISA, IHC, IF, FC |
GAA Recombinant Monoclonal Antibody | CSB-RA566370A0HU | GAA | Human | ELISA, IHC |
GCGR Recombinant Monoclonal Antibody | CSB-RA009316A1HU | GCGR | Human | ELISA |
GDF15 Recombinant Monoclonal Antibody | CSB-RA285852A0HU | GDF15 | Human | ELISA, IHC |
GHR Recombinant Monoclonal Antibody | CSB-RA978909A0HU | GHR | Human | ELISA, IHC, IF |
Gipr Recombinant Monoclonal Antibody | CSB-RA009438MA1MO | Gipr | Mouse、Rat | ELISA |
GIPR Recombinant Monoclonal Antibody | CSB-RA009438MA2HU | GIPR | Human | ELISA, WB |
GIPR Recombinant Monoclonal Antibody | CSB-RA009438MA1HU | GIPR | Human, Macaca fascicularis | ELISA |
GLP1R Recombinant Monoclonal Antibody | CSB-RA009514MA1HU | GLP1R | Human | ELISA |
IGF1R Recombinant Monoclonal Antibody | CSB-RA011087MA1HU | IGF1R | Human | ELISA, FC |
IL17A Recombinant Monoclonal Antibody | CSB-RA624104MA1HU | IL17A | Human | ELISA |
● ELISA试剂盒
产品名称 | 货号 | 靶点 | 检测范围 | 灵敏度 |
---|---|---|---|---|
Human angiopoietin-like protein 3,ANGPTL3 ELISA Kit | CSB-E11724h | ANGPTL3 | 78 pg/mL-5000 pg/mL | 19.5 pg/mL |
Mouse Angiopoietin-related protein 3(ANGPTL3) ELISA kit | CSB-EL001711MO | ANGPTL3 | 31.25 pg/mL-2000 pg/mL | 10.24 pg/mL |
Human apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E08103h | APOA1 | 1.4 ng/mL-1000 ng/mL | 0.7 ng/mL |
Rat apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E08105r | APOA1 | 0.14 ng/ml-100 ng/ml. | 0.14 ng/ml. |
Pig apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E06834p | APOA1 | 80 μg/mL-2000 μg/mL | 50 μg/mL |
Mouse apolipoprotein A1(Apo-A1) ELISA Kit | CSB-E08104m | APOA1 | 31.25 ng/mL-2000 ng/mL | 7.81 ng/mL |
Rabbit apolipoprotein A1 (Apo-A1) ELISA Kit | CSB-E09804Rb | APOA1 | 6.25 μg/mL-400 μg/mL | 1.56 μg/mL |
Bovine Apolipoprotein A-I(APOA1) ELISA kit | CSB-EL001913BO | APOA1 | 78 ng/mL-5000 ng/mL | 19.5 ng/mL |
Dog Apolipoprotein A-I(APOA1) ELISA kit | CSB-EL001913DO | APOA1 | 28.12 ng/mL-1800 ng/mL | 7 ng/mL |
Rat Amyloid beta A4 protein(APP) ELISA kit | CSB-EL001950RA | APP | 15.6 ng/mL-1000 ng/mL | 3.9 ng/mL |
Mouse Complement 5,C5 ELISA Kit | CSB-E13802m | C5 | 0.25 ng/mL-16 ng/mL | 0.06 ng/mL |
Rat Complement fragment 5,C5 ELISA Kit | CSB-E14363r | C5 | 9.38 ng/mL-600 ng/mL | 2.34 ng/mL |
Monkey complement C5 (C5) ELISA kit | CSB-EL003995MK | C5 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human Uncharacterized protein C9orf72(C9orf72) ELISA kit | CSB-EL004345HU | C9orf72 | 31.25 pg/mL-2000 pg/mL | 7.8 pg/mL |
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human soluble cluster of differentiation 28,sCD28 ELISA Kit | CSB-E09296h | CD28 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit | CSB-E09884h | CD38 | 0.9 ng/mL-60 ng/mL | 0.225 ng/mL |
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit | CSB-EL004929MO | CD38 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | CSB-EL004936MO | CD40 | Request Information | Request Information |
Human Soluble Cluster of differentiation 40 ligand,sCD40L ELISA Kit | CSB-E04716h | CD40LG | 0.312 ng/mL-20 ng/mL | 0.078 ng/mL |