胃癌
胃癌是起源于胃黏膜上皮细胞的恶性肿瘤,它是全球癌症死亡率较高的癌症之一。胃癌的发展可能与多种因素有关,包括遗传、不良饮食习惯、吸烟、酗酒、幽门螺杆菌感染等。根据肿瘤的生物学特征,胃癌也可以分为不同的亚型,如肠型、弥漫型和混合型等。
胃癌的治疗通常包括手术切除、化疗、放疗和靶向治疗等方法。近年来,胃癌的药物研发取得了显著进展,特别是在靶向治疗和免疫治疗领域。
- 靶向治疗药物主要针对胃癌细胞的特定分子靶点,如HER2、VEGFR、EGFR等。例如,对于HER2阳性的胃癌,曲妥珠单抗(Trastuzumab)是一种有效的治疗药物。此外,针对VEGFR和EGFR的小分子酪氨酸激酶抑制剂,如阿法替尼(Afatinib)和雷格拉替尼(Regorafenib),也在胃癌治疗中显示出一定的疗效。
- 免疫治疗是胃癌治疗领域的新兴方向,它通过激活患者自身的免疫系统来攻击癌细胞。免疫检查点抑制剂,如PD-1抑制剂帕博利珠单抗(Pembrolizumab)和CTLA-4抑制剂伊皮利莫单抗(Ipilimumab),已经在一些胃癌患者中显示出治疗潜力。这些药物通过解除肿瘤对免疫系统的抑制,增强免疫系统对癌细胞的攻击。
胃癌药物靶点
胃癌药物靶点相关产品推荐
● 靶点蛋白
CSB-MP007763HU
Measured by its binding ability in a functional ELISA. Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC50 is 2.179-2.825 ng/ml.
CSB-MP005498HU(A5)
Measured by its binding ability in a functional ELISA. Immobilized human CLDN18.2 at 5 μg/ml can bind anti-CLDN18.2 recombinant Monoclonal Antibody (CSB-RA005498A1HU), the the EC50 is 5.225-9.256 ng/ml.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP878942HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL
CSB-MP007479HU
Human EGF protein captured on COOH chip can bind Human EGFR protein, his and Myc tag (CSB-MP007479HU) with an affinity constant of 11.9nM as detected by LSPR Assay.
CSB-MP006163HU1
Measured by its binding ability in a functional ELISA. Immobilized CD152 at 2 μg/ml can bind Anti-CD152 rabbit monoclonal antibody (CSB-RA213310A0HU), the EC50 of human CD152 protein is 27.14-34.82 ng/ml.
Measured by its binding ability in a functional ELISA. Immobilized MET at 2 μg/ml can bind Anti-MET recombinant antibody, the EC50 is 2.379-3.094 ng/ml.
CSB-MP023997HU1
Measured by its binding ability in a functional ELISA. Immobilized TNFSF9 at 2 μg/ml can bind TNFRSF9(CSB-MP023984HU1), the EC50 is 2.671-3.702 ng/mL
● 稳定细胞株
CT26/Human ROR1 Stable Cell Line
Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
HEK293T/Human CDH17 Stable Cell Line
Untransfected HEK293T cells (green line) and transfected Human CDH17 HEK293T stable cells (red line) were stained with anti-CDH17 antibody (CSB-RA613267MA1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
● 重组抗体
CSB-RA613267MA1HU
Untransfected HEK293T cells surface (green line) and transfected Human CDH17 HEK293T stable cells surface (red line) were stained with anti-CDH17 antibody (2µg/1*106 cells).
CSB-RA010053A3HU
T84 cells were stained with Human IgG (green line) and anti-GUCY2C antibody (red line) (2µg/1*106 cells)。
CSB-RA006163MA1HU
Overlay Peak curve showing JK cells surface stained with CSB-RA006163MA1HU (red line) at 1:50.
CSB-RA792129A0HU
Overlay histogram showing HepG2 cells stained with CSB-RA792129A0HU (red line) at 1:50.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
CD55 Recombinant Monoclonal Antibody | CSB-RA440943A0HU | CD55 | Human | ELISA, WB, IHC |
CDH17 Recombinant Monoclonal Antibody | CSB-RA613267MA1HU | CDH17 | Human | ELISA,FC |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA3HU | CEACAM5 | Human | ELISA, IF, FC |
CEACAM5 Recombinant Monoclonal Antibody | CSB-RA005165MA1HU | CEACAM5 | Human | ELISA |
CLDN18 Recombinant Monoclonal Antibody | CSB-RA005498A2HU | CLDN18 | Human | ELISA, FC |
Claudin-18.2 Recombinant Monoclonal Antibody | CSB-RA005498A1HU | CLDN18 | Human | ELISA, FC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA213310A0HU | CTLA4 | Human | ELISA, IHC |
CTLA4 Recombinant Monoclonal Antibody | CSB-RA006163MA1HU | CTLA4 | Human, Mouse | ELISA, WB, IF, FC |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
EPCAM Recombinant Monoclonal Antibody | CSB-RA932207A0HU | EPCAM | Human | ELISA, WB |
EPCAM Recombinant Monoclonal Antibody | CSB-RA439934A0HU | EPCAM | Human | ELISA, WB, IHC |