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白血病

白血病是一种影响血液和骨髓的恶性肿瘤,它导致体内产生大量未成熟或异常的白细胞,这些异常细胞可能会抑制正常血细胞的产生,从而引发各种症状和并发症。白血病可以分为急性和慢性两大类,根据细胞类型又可分为髓系和淋巴系两种。急性白血病的细胞分化停滞在早期阶段,疾病发展迅速;而慢性白血病的细胞分化较好,发展缓慢。

白血病的药物研发近年来取得了显著进展。例如,靶向治疗药物如酪氨酸激酶抑制剂(TKI)在慢性髓系白血病(CML)的治疗中取得了巨大成功,极大地改善了患者的预后。特别是三代TKI新药的问世,为CML患者提供了更多的治疗选择和更好的疗效。

此外,CAR-T细胞疗法作为一种新兴的免疫治疗方法,已经在某些类型的白血病治疗中显示出突破性的疗效。CAR-T疗法通过改造患者的T细胞,使其能够识别并攻击癌细胞。中国在CAR-T疗法的研发上也取得了进展,已有产品获批上市,为患者提供了新的治疗选择。

全球范围内,针对白血病治疗的药物研发非常活跃,处于在研阶段的药物有上千个。其中靶向CD19的药物数量最多,其次是Flt3抑制剂。中国在白血病治疗药物研发方面也取得了进展,例如,基石药业的艾伏尼布(Ivosidenib)在中国的注册研究显示了明确的疗效和可控的安全性,有望成为中国首个获批的IDH1抑制剂。

白血病药物靶点相关产品推荐

● 靶点蛋白

CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL

CSB-MP004900HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD22 at 2 μg/ml can bind Anti-CD22 rabbit monoclonal antibody, the EC50 of human CD22 protein is 4.034-4.800 ng/ml.

CSB-MP004925HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD33 at 2 μg/ml can bind Anti-CD33 rabbit monoclonal antibody, the EC50 of human CD33 protein is 4.289- 5.312 ng/ml.

CSB-MP004940HU Activity Verified

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP878942HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-L1 at 2 μg/ml can bind Anti- PD-L1 mouse monoclonal antibody (CSB-MA878942A1m, antigen from E.coli), the EC50 of human PD-L1 protein is 1.252-1.653 ng/mL

CSB-MP023983HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized CD30 at 5 μg/ml can bind human CD30L(CSB-MP023996HU1c9), the EC50 is 14.96-20.25 ng/ml

CSB-MP004936HU1 Activity Verified

Human CD40 protein hFc tag (CSB-MP004936HU1) captured on COOH chip can bind Human CD40L protein hFc and Flag tag (CSB-MP004937HU3) with an affinity constant of 2.06 nM as detected by LSPR Assay

产品名称 货号 靶点 来源 蛋白标签
Recombinant Human C-C chemokine receptor type 4 (CCR4)-VLPs (Active) CSB-MP004843HU CCR4 Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active) CSB-AP005061HU CD19 Mammalian cell C-terminal Fc-tagged
Recombinant Human B-cell receptor CD22 (CD22), partial (Active) CSB-MP004900HU CD22 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human Myeloid cell surface antigen CD33 (CD33), partial (Active) CSB-MP004925HU CD33 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial (Active) CSB-MP004938HU(F1) CD44 Mammalian cell C-terminal hFc-tagged
Recombinant Human CD44 antigen (CD44), partial, Biotinylated (Active) CSB-MP004938HU(F1)j1-B CD44 Mammalian cell C-terminal mFc-Avi-tagged
Recombinant Macaca fascicularis CD44 antigen (CD44), partial (Active) CSB-MP4290MOV CD44 Mammalian cell C-terminal 10xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human T-cell antigen CD7 (CD7), partial (Active) CSB-MP004953HU CD7 Mammalian cell C-terminal hFc-Myc-tagged
Recombinant Human CD70 antigen (CD70), partial (Active) CSB-MP004954HU1 CD70 Mammalian cell N-terminal 10xHis-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active) CSB-AP003591HU CSF2RA Mammalian cell C-terminal 6xHis-tagged
Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4 (CTLA4), partial (Active) CSB-AP005121GU CTLA4 Yeast C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-AP005231HU CTLA4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Mouse Cytotoxic T-lymphocyte protein 4 (Ctla4), partial (Active) CSB-AP005301MO Ctla4 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Cytotoxic T-lymphocyte protein 4 (CTLA4), partial (Active) CSB-MP006163HU1 CTLA4 Mammalian cell C-terminal hFc-tagged

● 稳定细胞株

CSB-SC004843HU2
CSB-SC004843HU2 FACS

HEK293T/Human CCR4 Stable Cell Line

Untransfected HEK293T cells (green line) and transfected Human CCR4 HEK293T stable cells (red line) were stained with anti-CCR4 antibody (CSB-MA236376) (2µg/1*106), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CSB-SC020067HU
CSB-SC020067HU FACS

CT26/Human ROR1 Stable Cell Line

Untransfected CT26 cells (green line) and transfected Human ROR1 CT26 stable cells (red line) were stained with anti-ROR1 antibody (CSB-RA020067A1HU) (2µg/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

● 重组抗体

CCR4 Recombinant Monoclonal Antibody
CSB-RA004843MA01HU
CSB-RA004843MA01HU FC

Untransfected HEK293 cells surface (green line) and transfected Human CCR4 HEK293 stable cells surface (red line) were stained with anti-CCR4 antibody (2µl/1*106 cells)

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU
CSB-RA244537A0HU FC

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

CD3E Recombinant Monoclonal Antibody
CSB-RA004931MA1HU
CSB-RA004931MA1HU FC

Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100.

CD44 Recombinant Monoclonal Antibody
CSB-RA004938MA1HU
CSB-RA004938MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA004938MA1HU (red line) at 1:100.

产品名称 货号 靶点 反应种属 应用范围
CCR4 Recombinant Monoclonal Antibody CSB-RA004843MA01HU CCR4 Human ELISA, FC
CD19 Recombinant Monoclonal Antibody CSB-RA004888A0HU CD19 Human ELISA
CD19 Recombinant Monoclonal Antibody CSB-RA780821A0HU CD19 Human ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody CSB-RA004888MA1HU CD19 Human, Mouse ELISA, WB
CD22 Recombinant Monoclonal Antibody CSB-RA962691A0HU CD22 Human ELISA, IHC
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody CSB-RA796695A0HU CD38 Human ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody CSB-RA004931MA1HU CD3E Human ELISA, FC
CD4 Recombinant Monoclonal Antibody CSB-RA004935A0HU CD4 Human ELISA, WB, IHC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD44 Recombinant Monoclonal Antibody CSB-RA004938A0HU CD44 Human ELISA, WB, IHC
CD44 Recombinant Monoclonal Antibody CSB-RA292372A0HU CD44 Human ELISA, WB, IHC, IF, FC
CD44 Recombinant Monoclonal Antibody CSB-RA004938MA1HU CD44 Human ELISA, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
CD70 Recombinant Monoclonal Antibody CSB-RA004954MA1HU CD70 Human ELISA
CTLA4 Recombinant Monoclonal Antibody CSB-RA213310A0HU CTLA4 Human ELISA, IHC
CTLA4 Recombinant Monoclonal Antibody CSB-RA006163MA1HU CTLA4 Human, Mouse ELISA, WB, IF, FC
CXCR4 Recombinant Monoclonal Antibody CSB-RA569311A0HU CXCR4 Human ELISA, IF

● ELISA试剂盒

产品名称 货号 靶点 检测范围 灵敏度
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Myeloid cell surface antigen CD33(CD33) ELISA kit CSB-EL004925HU CD33 125 pg/mL-8000 pg/mL 31.25 pg/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit CSB-E09884h CD38 0.9 ng/mL-60 ng/mL 0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit CSB-EL004929MO CD38 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human cluster of differentiation 4,CD4 ELISA Kit CSB-E08956h CD4 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Rat cluster of differentiation 4,CD4 ELISA Kit CSB-E12928r CD4 0.78 U/mL-50 U/mL 0.195 U/mL
Chicken Cluster of Differentiation 4(CD4) ELISA Kit CSB-E13114C CD4 3.125 ng/mL-800 ng/mL 3.125 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human cluster Of differentiation,CD44 ELISA Kit CSB-E11846h CD44 78 pg/mL-5000 pg/mL 19.5 pg/mL
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human CAMPATH-1 antigen(CD52) ELISA kit CSB-EL004943HU CD52 78 ng/mL-5000 ng/mL 19.5 ng/mL
Mouse cluster of differentiation 6(CD6) ELISA Kit CSB-EL004949MO CD6 Request Information Request Information
Human CD70 antigen(CD70) ELISA kit CSB-EL004954HU CD70 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Mouse CD70 antigen(CD70) ELISA kit CSB-EL004954MO CD70 Request Information Request Information
Human cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E09171h CTLA4 125 pg/mL-8000 pg/mL 31.25 pg/mL
Mouse cytotoxic T lymphocyte associated antigen 4,CTLA-4 ELISA Kit CSB-E13637m CTLA4 0.312 ng/mL-20 ng/mL 0.078 ng/mL
Rat CXC-chemokine receptor 4(CXCR4)ELISA Kit CSB-E12703r CXCR4 0.156 ng/mL-10 ng/mL 0.039 ng/mL