心血管疾病
心血管疾病是影响心脏和血管系统的一类疾病,包括心脏病和外周血管疾病。心脏病主要涉及心脏结构的异常,如冠状动脉疾病,它是由于冠状动脉供血不足导致心肌缺血或缺氧。外周血管疾病则影响除心脏外的血管,如上肢、下肢及躯干的供血血管异常。
针对特定受体和信号通路的靶向治疗是心血管疾病药物研发的重要方向,如:
- G蛋白偶联受体(GPCR):GPCR是一大类细胞表面受体,它们在心血管系统中调节多种生理过程,包括血压和心率的控制。Apelin受体(APLNR)是GPCR家族的一员,它在心血管疾病中具有潜在的治疗作用。通过设计特异性激动剂,可以激活G蛋白信号通路,减少有害的心肌肥厚,为心力衰竭治疗提供新策略。
- 血栓素A2受体(TP):TP是血小板聚集和血管平滑肌细胞收缩的关键调节因子,是治疗动脉粥样硬化和高血压的潜在靶点。通过研究TP与其配体的结合模式,可以设计出特异性的TP抑制剂,以减少心血管疾病的发生。
- 离子通道:心脏和血管平滑肌细胞的离子通道在调节心脏节律和血管张力中起着核心作用。针对特定离子通道的药物,如钙通道阻滞剂,已经被广泛用于治疗高血压和心绞痛。
- 酶抑制剂:例如,血管紧张素转换酶(ACE)抑制剂和血管紧张素受体阻滞剂(ARBs)通过阻断肾素-血管紧张素系统来降低血压,减少心血管疾病的风险。
- 脂肪酸和脂质代谢调节剂:他汀类药物通过抑制HMG-CoA还原酶来降低胆固醇水平,减少心血管疾病的风险。
- 抗凝血药物:通过减少血液凝固来预防血栓形成,用于治疗或预防中风和心肌梗死。
心血管疾病药物靶点
- ANGPT2
- ANGPTL3
- C1R
- C1S
- C5
- CD19
- CD247
- CD274
- CD38
- CD3E
- CD40
- CD47
- CSF2RA
- CSF3R
- DNA2
- DRD4
- EGFR
- EpoR
- ERBB2
- F10
- F11
- F5
- F7
- F8
- F9
- FLT1
- GHR
- GLP1R
- GPRC5D
- HGF
- HLA-DRA
- ICAM1
- IFNAR1
- IGF1R
- IL1B
- IL1R1
- IL2RA
- IL5
- IL6
- IL6R
- IL6ST
- INSR
- KIT
- KLKB1
- MPL
- MS4A1
- NGFR
- NPR1
- PCSK9
- PDCD1
- PDGFRB
- PGF
- PKP2
- PLG
- PTCRA
- RXFP1
- SDC1
- SELE
- SELP
- SLAMF7
- TIGIT
- TNF
- TNFRSF17
- TNFSF11
- TNFSF13
- TTR
- VEGFA
- VEGFD
- VWF
心血管疾病靶点相关产品推荐
● 靶点蛋白
CSB-MP023974HU1
Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.
Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.
CSB-MP015007HU
Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL
CSB-MP004940HU
Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.
CSB-MP882153HU
Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D at 5 μg/mL can bind Anti-GPRC5D recombinant antibody (CSB-RA882153MA01HU), the EC50 is 8.847-10.38 ng/mL.
Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU),the EC50 is 35.80-41.82 ng/mL.
CSB-MP619964HU1
Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.
CSB-MP001707HU(A4)
Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL
● 重组抗体
CSB-RA244537A0HU
Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.
CSB-RA011087MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.
CSB-RA159341A0HU
Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.
CSB-RA878942MA1HU
Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.
产品名称 | 货号 | 靶点 | 反应种属 | 应用范围 |
---|---|---|---|---|
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA191985A0HU | ANGPT2 | Human | ELISA, IHC |
ANGPT2 Recombinant Monoclonal Antibody | CSB-RA001707MA01HU | ANGPT2 | Human | ELISA |
C5 Recombinant Monoclonal Antibody | CSB-RA003995MA1HU | C5 | Human | ELISA, FC |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888A0HU | CD19 | Human | ELISA |
CD19 Recombinant Monoclonal Antibody | CSB-RA780821A0HU | CD19 | Human | ELISA, WB, IHC, IP |
CD19 Recombinant Monoclonal Antibody | CSB-RA004888MA1HU | CD19 | Human, Mouse | ELISA, WB |
CD247 Recombinant Monoclonal Antibody | CSB-RA244537A0HU | CD247 | Human | ELISA, FC |
CD274 Recombinant Monoclonal Antibody | CSB-RA977797A0HU | CD274 | Human | ELISA, WB, IHC |
CD274 Recombinant Monoclonal Antibody | CSB-RA878942MA1HU | CD274 | Human | ELISA, IHC, FC |
CD38 Recombinant Monoclonal Antibody | CSB-RA796695A0HU | CD38 | Human | ELISA, WB, IHC |
CD3E Recombinant Monoclonal Antibody | CSB-RA004931MA1HU | CD3E | Human | ELISA, FC |
CD40 Recombinant Monoclonal Antibody | CSB-RA004936MA1HU | CD40 | Human | ELISA, IF, FC |
CD47 Recombinant Monoclonal Antibody | CSB-RA802124A0HU | CD47 | Human | ELISA, WB, IHC, IF |
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody | CSB-RA007479A1092phHU | EGFR | Human | ELISA, WB |
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody | CSB-RA007479A1068phHU | EGFR | Human | ELISA, WB |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341A0HU | EGFR | Human | ELISA, WB, IHC, IF, FC |
EGFR Recombinant Monoclonal Antibody | CSB-RA794061A0HU | EGFR | Human | ELISA, WB, IHC |
EGFR Recombinant Monoclonal Antibody | CSB-RA159341MA1HU | EGFR | Human | ELISA, IHC, FC |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA260392A0HU | ERBB2 | Human | ELISA, IHC, IF |
ERBB2 Recombinant Monoclonal Antibody | CSB-RA007763MA1HU | ERBB2 | Human | ELISA |
● ELISA试剂盒
产品名称 | 货号 | 靶点 | 检测范围 | 灵敏度 |
---|---|---|---|---|
Human Angiopoietin 2,ANG-2 ELISA Kit | CSB-E04500h | ANGPT2 | 39 pg/mL-2500 pg/mL | 9.75 pg/mL |
Rat Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07304r | ANGPT2 | Request Information | Request Information |
Mouse Angiopoietin 2,ANG-2 ELISA Kit | CSB-E07305m | ANGPT2 | 0.156 pg/mL-10 pg/mL | 0.039 pg/mL |
Pig Angiopoietin 2,ANG-2 ELISA Kit | CSB-E08460p | ANGPT2 | 0.94 ng/mL-60 ng/mL | 0.235 ng/mL |
Human angiopoietin-like protein 3,ANGPTL3 ELISA Kit | CSB-E11724h | ANGPTL3 | 78 pg/mL-5000 pg/mL | 19.5 pg/mL |
Mouse Angiopoietin-related protein 3(ANGPTL3) ELISA kit | CSB-EL001711MO | ANGPTL3 | 31.25 pg/mL-2000 pg/mL | 10.24 pg/mL |
Human Complement C1s subcomponent(C1S) ELISA kit | CSB-EL003657HU | C1S | 25 ng/mL-1600 ng/mL | 6.25 ng/mL |
Mouse Complement 5,C5 ELISA Kit | CSB-E13802m | C5 | 0.25 ng/mL-16 ng/mL | 0.06 ng/mL |
Rat Complement fragment 5,C5 ELISA Kit | CSB-E14363r | C5 | 9.38 ng/mL-600 ng/mL | 2.34 ng/mL |
Monkey complement C5 (C5) ELISA kit | CSB-EL003995MK | C5 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit | CSB-EL004904HU | CD247 | 0.156 ng/mL-10 ng/mL | 0.039 ng/mL |
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit | CSB-E13644h | CD274 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit | CSB-EL004911MO | CD274 | 31.25 pg/mL-2000 pg/mL | 7.81 pg/mL |
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit | CSB-E09884h | CD38 | 0.9 ng/mL-60 ng/mL | 0.225 ng/mL |
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit | CSB-EL004929MO | CD38 | 0.625 ng/mL-40 ng/mL | 0.156 ng/mL |
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit | CSB-EL004936MO | CD40 | Request Information | Request Information |
Human Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940HU | CD47 | 3.12 pg/mL-200 pg/mL | 0.78 pg/mL |
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit | CSB-EL004940MO | CD47 | 15.6 pg/mL-1000 pg/mL | 3.9 pg/mL |
Human epidermal growth factor receptor,EGFR ELISA Kit | CSB-E12124h | EGFR | 0.312 ng/mL-20 ng/mL | 0.019 ng/mL |
Human Erythropoietin receptor,EPOR ELISA Kit | CSB-E04537h | EPOR | 0.156 ng/ml - 10 ng/ml | 0.039 ng/ml |