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心血管疾病

心血管疾病是影响心脏和血管系统的一类疾病,包括心脏病和外周血管疾病。心脏病主要涉及心脏结构的异常,如冠状动脉疾病,它是由于冠状动脉供血不足导致心肌缺血或缺氧。外周血管疾病则影响除心脏外的血管,如上肢、下肢及躯干的供血血管异常。

针对特定受体和信号通路的靶向治疗是心血管疾病药物研发的重要方向,如:

  • G蛋白偶联受体(GPCR):GPCR是一大类细胞表面受体,它们在心血管系统中调节多种生理过程,包括血压和心率的控制。Apelin受体(APLNR)是GPCR家族的一员,它在心血管疾病中具有潜在的治疗作用。通过设计特异性激动剂,可以激活G蛋白信号通路,减少有害的心肌肥厚,为心力衰竭治疗提供新策略。
  • 血栓素A2受体(TP):TP是血小板聚集和血管平滑肌细胞收缩的关键调节因子,是治疗动脉粥样硬化和高血压的潜在靶点。通过研究TP与其配体的结合模式,可以设计出特异性的TP抑制剂,以减少心血管疾病的发生。
  • 离子通道:心脏和血管平滑肌细胞的离子通道在调节心脏节律和血管张力中起着核心作用。针对特定离子通道的药物,如钙通道阻滞剂,已经被广泛用于治疗高血压和心绞痛。
  • 酶抑制剂:例如,血管紧张素转换酶(ACE)抑制剂和血管紧张素受体阻滞剂(ARBs)通过阻断肾素-血管紧张素系统来降低血压,减少心血管疾病的风险。
  • 脂肪酸和脂质代谢调节剂:他汀类药物通过抑制HMG-CoA还原酶来降低胆固醇水平,减少心血管疾病的风险。
  • 抗凝血药物:通过减少血液凝固来预防血栓形成,用于治疗或预防中风和心肌梗死。

心血管疾病靶点相关产品推荐

● 靶点蛋白

CSB-MP023974HU1 Activity Verified

Human TNFSF13B protein Fc tag (CSB-MP897523HU1) captured on COOH chip can bind Human BCMA protein Fc tag (CSB-MP023974HU1) with an affinity constant of 39 nM as detected by LSPR Assay.

CSB-MP009411HU Activity Verified

Human GH1 protein his/myc tag (CSB-MP009407HU) captured on COOH chip can bind Human GHR protein Fc tag (CSB-MP009411HU) with an affinity constant of 6.1 nM as detected by LSPR Assay.

MS4A1 (CD20)
CSB-MP015007HU
CSB-MP015007HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized human CD20 at 2 μg/ml can bind Anti-CD20 recombinant antibody (CSB-RA015007A1HU), the EC50 is 3.243-7.085 ng/mL

CSB-MP004940HU Activity Verified

Human SIRPA protein His/Myc tag (CSB-MP021334HU) captured on COOH chip can bind Human CD47 protein Fc tag (CSB-MP004940HU) with an affinity constant of 19.1 nM as detected by LSPR Assay.

CSB-MP882153HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human GPRC5D at 5 μg/mL can bind Anti-GPRC5D recombinant antibody (CSB-RA882153MA01HU), the EC50 is 8.847-10.38 ng/mL.

CSB-YP011664HU Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human IL6 at 2μg/mL can bind Anti-IL6 recombinant antibody (CSB-RA011664MA1HU),the EC50 is 35.80-41.82 ng/mL.

CSB-MP619964HU1 Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized PD-1 at 2 μg/ml can bind Anti-PD-1 recombinant antibody, the EC50 of human PD-1 protein is 6.087-7.854 ng/ml.

CSB-MP001707HU(A4) Activity Verified

Measured by its binding ability in a functional ELISA. Immobilized Human ANGPT2 at 2 μg/ml can bind anti-ANGPT2 recombinant antibody(CSB-RA001707MA01HU), the EC50 is 0.6666-0.8876 ng/mL

产品名称 货号 靶点 来源 蛋白标签
Recombinant Human Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707HU(A4) ANGPT2 Mammalian cell C-terminal 10xHis-tagged
Recombinant Dog Angiopoietin-2 (ANGPT2) (Active) CSB-MP001707DO ANGPT2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human B-lymphocyte antigen CD19 (CD19), partial (Active) CSB-AP005061HU CD19 Mammalian cell C-terminal Fc-tagged
Recombinant Human Programmed cell death 1 ligand 1 (CD274), partial (Active) CSB-MP878942HU1 CD274 Mammalian cell C-terminal hFc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-AP005181HU CD40 Mammalian cell C-terminal Fc-tagged
Recombinant Human Tumor necrosis factor receptor superfamily member 5 (CD40), partial (Active) CSB-MP004936HU1 CD40 Mammalian cell C-terminal hFc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005201HU CD47 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-AP005211HU CD47 Mammalian cell C-terminal Fc-tagged
Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active) CSB-MP004940HU CD47 Mammalian cell C-terminal hFc-tagged
Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA), partial (Active) CSB-AP003591HU CSF2RA Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Epidermal growth factor receptor (EGFR), partial (Active) CSB-MP007479HU EGFR Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human Receptor tyrosine-protein kinase erbB-2 (ERBB2), partial (Active) CSB-MP007763HU ERBB2 Mammalian cell C-terminal 6xHis-tagged
Recombinant Human Growth hormone receptor (GHR), partial (Active) CSB-MP009411HU GHR Mammalian cell C-terminal hFc-tagged
Recombinant Human Growth hormone receptor (GHR), partial, Biotinylated (Active) CSB-MP009411HUj1-B GHR Mammalian cell C-terminal mFc-Avi-tagged
Recombinant Human Glucagon-like peptide 1 receptor (GLP1R), partial (Active) CSB-MP009514HUb1 GLP1R Mammalian cell N-terminal 10xHis-tagged and C-terminal Myc-tagged
Recombinant Human G-protein coupled receptor family C group 5 member D (GPRC5D)-VLPs (Active) CSB-MP882153HU GPRC5D Mammalian cell C-terminal 10xHis-tagged (This tag can be tested only under denaturing conditions)
Recombinant Human Hepatocyte growth factor (HGF) (Active) CSB-AP003681HU HGF Mammalian cell C-terminal 6xHis-tagged
Recombinant Rhesus Macaque Interleukin-1 beta protein (IL1B) (Active) CSB-AP003081MOW IL1B E.Coli Tag-Free
Recombinant Mouse Interleukin-1 beta protein (Il1b) (Active) CSB-AP003261MO Il1b E.Coli Tag-Free
Recombinant Horse Interleukin-1 beta protein (IL1B) (Active) CSB-AP003481HO IL1B E.Coli Tag-Free

● 重组抗体

CD247 Recombinant Monoclonal Antibody
CSB-RA244537A0HU
CSB-RA244537A0HU FC

Overlay Peak curve showing Jurkat cells surface stained with CSB-RA244537A0HU (red line) at 1:50.

IGF1R Recombinant Monoclonal Antibody
CSB-RA011087MA1HU
CSB-RA011087MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA011087MA1HU (red line) at 1:50.

EGFR Recombinant Monoclonal Antibody
CSB-RA159341A0HU
CSB-RA159341A0HU FC

Overlay histogram showing Jurkat cells stained with CSB-RA159341A0HU (red line) at 1:50.

CD274 Recombinant Monoclonal Antibody
CSB-RA878942MA1HU
CSB-RA878942MA1HU FC

Overlay Peak curve showing Hela cells surface stained with CSB-RA878942MA1HU (red line) at 1:100.

产品名称 货号 靶点 反应种属 应用范围
ANGPT2 Recombinant Monoclonal Antibody CSB-RA191985A0HU ANGPT2 Human ELISA, IHC
ANGPT2 Recombinant Monoclonal Antibody CSB-RA001707MA01HU ANGPT2 Human ELISA
C5 Recombinant Monoclonal Antibody CSB-RA003995MA1HU C5 Human ELISA, FC
CD19 Recombinant Monoclonal Antibody CSB-RA004888A0HU CD19 Human ELISA
CD19 Recombinant Monoclonal Antibody CSB-RA780821A0HU CD19 Human ELISA, WB, IHC, IP
CD19 Recombinant Monoclonal Antibody CSB-RA004888MA1HU CD19 Human, Mouse ELISA, WB
CD247 Recombinant Monoclonal Antibody CSB-RA244537A0HU CD247 Human ELISA, FC
CD274 Recombinant Monoclonal Antibody CSB-RA977797A0HU CD274 Human ELISA, WB, IHC
CD274 Recombinant Monoclonal Antibody CSB-RA878942MA1HU CD274 Human ELISA, IHC, FC
CD38 Recombinant Monoclonal Antibody CSB-RA796695A0HU CD38 Human ELISA, WB, IHC
CD3E Recombinant Monoclonal Antibody CSB-RA004931MA1HU CD3E Human ELISA, FC
CD40 Recombinant Monoclonal Antibody CSB-RA004936MA1HU CD40 Human ELISA, IF, FC
CD47 Recombinant Monoclonal Antibody CSB-RA802124A0HU CD47 Human ELISA, WB, IHC, IF
Phospho-EGFR (Y1092) Recombinant Monoclonal Antibody CSB-RA007479A1092phHU EGFR Human ELISA, WB
Phospho-EGFR (Y1068) Recombinant Monoclonal Antibody CSB-RA007479A1068phHU EGFR Human ELISA, WB
EGFR Recombinant Monoclonal Antibody CSB-RA159341A0HU EGFR Human ELISA, WB, IHC, IF, FC
EGFR Recombinant Monoclonal Antibody CSB-RA794061A0HU EGFR Human ELISA, WB, IHC
EGFR Recombinant Monoclonal Antibody CSB-RA159341MA1HU EGFR Human ELISA, IHC, FC
ERBB2 Recombinant Monoclonal Antibody CSB-RA260392A0HU ERBB2 Human ELISA, IHC, IF
ERBB2 Recombinant Monoclonal Antibody CSB-RA007763MA1HU ERBB2 Human ELISA

● ELISA试剂盒

产品名称 货号 靶点 检测范围 灵敏度
Human Angiopoietin 2,ANG-2 ELISA Kit CSB-E04500h ANGPT2 39 pg/mL-2500 pg/mL 9.75 pg/mL
Rat Angiopoietin 2,ANG-2 ELISA Kit CSB-E07304r ANGPT2 Request Information Request Information
Mouse Angiopoietin 2,ANG-2 ELISA Kit CSB-E07305m ANGPT2 0.156 pg/mL-10 pg/mL 0.039 pg/mL
Pig Angiopoietin 2,ANG-2 ELISA Kit CSB-E08460p ANGPT2 0.94 ng/mL-60 ng/mL 0.235 ng/mL
Human angiopoietin-like protein 3,ANGPTL3 ELISA Kit CSB-E11724h ANGPTL3 78 pg/mL-5000 pg/mL 19.5 pg/mL
Mouse Angiopoietin-related protein 3(ANGPTL3) ELISA kit CSB-EL001711MO ANGPTL3 31.25 pg/mL-2000 pg/mL 10.24 pg/mL
Human Complement C1s subcomponent(C1S) ELISA kit CSB-EL003657HU C1S 25 ng/mL-1600 ng/mL 6.25 ng/mL
Mouse Complement 5,C5 ELISA Kit CSB-E13802m C5 0.25 ng/mL-16 ng/mL 0.06 ng/mL
Rat Complement fragment 5,C5 ELISA Kit CSB-E14363r C5 9.38 ng/mL-600 ng/mL 2.34 ng/mL
Monkey complement C5 (C5) ELISA kit CSB-EL003995MK C5 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Human T-cell surface glycoprotein CD3 zeta chain (CD247) ELISA kit CSB-EL004904HU CD247 0.156 ng/mL-10 ng/mL 0.039 ng/mL
Human Programmed Death Ligand-1(PD-L1/CD274) ELISA Kit CSB-E13644h CD274 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Mouse Programmed cell death 1 ligand 1(CD274) ELISA kit CSB-EL004911MO CD274 31.25 pg/mL-2000 pg/mL 7.81 pg/mL
Human Soluble Cluster of differentiation 38,sCD38 ELISA Kit CSB-E09884h CD38 0.9 ng/mL-60 ng/mL 0.225 ng/mL
Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit CSB-EL004929MO CD38 0.625 ng/mL-40 ng/mL 0.156 ng/mL
Mouse Tumor necrosis factor receptor superfamily member 5(CD40) ELISA kit CSB-EL004936MO CD40 Request Information Request Information
Human Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940HU CD47 3.12 pg/mL-200 pg/mL 0.78 pg/mL
Mouse Leukocyte surface antigen CD47(CD47) ELISA kit CSB-EL004940MO CD47 15.6 pg/mL-1000 pg/mL 3.9 pg/mL
Human epidermal growth factor receptor,EGFR ELISA Kit CSB-E12124h EGFR 0.312 ng/mL-20 ng/mL 0.019 ng/mL
Human Erythropoietin receptor,EPOR ELISA Kit CSB-E04537h EPOR 0.156 ng/ml - 10 ng/ml 0.039 ng/ml